KEGG   ORTHOLOGY: K24149
Entry
K24149                      KO                                     

Name
pp1ab
Definition
SARS coronavirus replicase polyprotein 1ab
Pathway
ko03230  Viral genome structure
ko05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24149  pp1ab; SARS coronavirus replicase polyprotein 1ab
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24149  pp1ab; SARS coronavirus replicase polyprotein 1ab
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24149  pp1ab; SARS coronavirus replicase polyprotein 1ab
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24149  pp1ab; SARS coronavirus replicase polyprotein 1ab
Genes
VG: 1489680(ORF1ab) 43740578(ORF1ab) 9714832(ORF1ab)
Reference
  Authors
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ
  Title
A new coronavirus associated with human respiratory disease in China.
  Journal
Nature 10.1038/s41586-020-2008-3 (2020)
DOI:10.1038/s41586-020-2008-3
  Sequence
Reference
  Authors
Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R
  Title
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
  Journal
Science eabb3405 (2020)
DOI:10.1126/science.abb3405
Reference
  Authors
Chen Y, Liu Q, Guo D
  Title
Emerging coronaviruses: Genome structure, replication, and pathogenesis.
  Journal
J Med Virol 92:418-423 (2020)
DOI:10.1002/jmv.25681
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