KEGG ORTHOLOGY: K24622

ORTHOLOGY: K24622

Entry

K24622                      KO

Symbol

CERS3, LASS3

Name

very-long-chain ceramide synthase / ultra-long-chain ceramide synthase [EC:2.3.1.297 2.3.1.298]

Pathway

map00600

Sphingolipid metabolism

map01100

Metabolic pathways

map04071

Sphingolipid signaling pathway

Module

M00094

Ceramide biosynthesis

M00099

Sphingosine biosynthesis

Reaction

R01496

acyl-CoA:sphingosine N-acyltransferase

R06517

acyl-CoA:sphingosine N-acyltransferase

Disease

H00734

Autosomal recessive congenital ichthyosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K24622  CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase
09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K24622  CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.297  very-long-chain ceramide synthase
     K24622  CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase
    2.3.1.298  ultra-long-chain ceramide synthase
     K24622  CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase

Other DBs

GO:

0050291

Genes

HSA:	204219(CERS3)

PTR:	453683(CERS3)

PPS:	100994802(CERS3)

GGO:	101128445(CERS3)

PON:	100451535(CERS3)

PPYG:

129013968(CERS3)

NLE:	100590821(CERS3)

HMH:	116481441(CERS3)

SSYN:

129481997(CERS3)

MCC:	693696(CERS3)

MCF:	102143963(CERS3)

MTHB:

126960139

MNI:	105499260(CERS3)

CSAB:

103231276(CERS3)

CATY:

105593986(CERS3)

PANU:

101007923(CERS3)

TGE:	112628897(CERS3)

MLEU:

105528481(CERS3)

RRO:	104676807(CERS3)

RBB:	108512618(CERS3)

TFN:	117070128(CERS3)

PTEH:

111527358(CERS3)

CANG:

105522836(CERS3)

CJC:	100406591(CERS3)

SBQ:	101042956(CERS3)

CIMI:

108296303(CERS3)

ANAN:

105707616(CERS3)

CSYR:

103271544(CERS3)

MMUR:

105871278(CERS3)

LCAT:

123644504(CERS3)

PCOQ:

105808927(CERS3)

OGA:	100941752(CERS3)

MMU:	545975(Cers3)

MCAL:

110299355(Cers3)

MPAH:

110333640(Cers3)

RNO:	499174(Cers3)

MCOC:

116102359(Cers3)

ANU:	117711260(Cers3)

MUN:	110546438(Cers3)

CGE:	100770521(Cers3)

MAUA:

101843120(Cers3)

PLEU:

114695508(Cers3)

MORG:

121450848(Cers3)

MFOT:

126505930

AAMP:

119802861(Cers3)

NGI:	103747188(Cers3)

HGL:	101702770(Cers3)

CPOC:

100712857(Cers3)

CCAN:

109700448(Cers3)

DORD:

105982319(Cers3)

DSP:	122123985(Cers3)

PLOP:

125368509(Cers3)

NCAR:

124976987

OCU:

100337851

OPI:	101520281(CERS3)

TUP:	102475021(CERS3)

GVR:	103586925(CERS3)

CFA:	607925(CERS3)

CLUD:

112653663(CERS3)

VVP:	112923446(CERS3)

VLG:	121489824(CERS3)

NPO:	129510158(CERS3)

AML:	100466254(CERS3)

UMR:	103659988(CERS3)

UAH:	113263637(CERS3)

UAR:	123790831(CERS3)

ELK:

111152682

LLV:

125105651

MPUF:

101687825(CERS3)

MNP:	132029106(CERS3)

MLK:	131835689(CERS3)

NVS:	122893869(CERS3)

ORO:	101381953(CERS3)

EJU:	114223819(CERS3)

ZCA:	113909841(CERS3)

MLX:	118022993(CERS3)

NSU:	110572365(CERS3)

LWW:	102728855(CERS3)

FCA:	101099301(CERS3)

PYU:	121042489(CERS3)

PCOO:

112856057(CERS3)

PBG:	122468302(CERS3)

PVIV:

125168995(CERS3)

LRUF:

124517427

PTG:	102968533(CERS3)

PPAD:

109273347(CERS3)

PUC:

125910240

AJU:

106972088

HHV:	120233673(CERS3)

BTA:	614354(CERS3)

BOM:	102282323(CERS3)

BIU:	109575125(CERS3)

BBUB:

102405478(CERS3)

BBIS:

104992832(CERS3)

CHX:	102169911(CERS3)

OAS:	101110093(CERS3)

BTAX:

128066892(CERS3)

CSUM:

138095500(CERS3)

ODA:	120875266(CERS3)

CCAD:

122455117(CERS3)

MREE:

136147476(CERS3)

MBEZ:

129550217(CERS3)

SSC:	100152265(CERS3)

CFR:	102505196(CERS3)

CBAI:

105075152(CERS3)

CDK:	105093450(CERS3)

VPC:	102533284(CERS3)

BACU:

103016103(CERS3)

BMUS:

118890439(CERS3)

LVE:	103082414(CERS3)

OOR:	101287722(CERS3)

DLE:	111187344(CERS3)

PCAD:

102975484(CERS3)

PSIU:

116749338(CERS3)

NASI:

112390989(CERS3)

ECB:	100050135(CERS3)

EPZ:	103561069(CERS3)

EAI:	106839474(CERS3)

MYB:	102242969(CERS3)

MYD:	102759130(CERS3)

MMYO:

118679202(CERS3)

MLF:	102428338(CERS3)

MDT:	132217889 132222995(CERS3)

PKL:	118704309(CERS3)

EFUS:

103301954(CERS3)

MNA:	107527642(CERS3)

DRO:	112306075(CERS3)

SHON:

118992022(CERS3)

AJM:	119049767(CERS3)

PDIC:

114488632(CERS3)

PHAS:

123809741(CERS3)

MMF:	118640928(CERS3)

PPAM:

129061294(CERS3)

HAI:	109380354(CERS3)

RFQ:	117018868(CERS3)

PALE:

102889613(CERS3)

PGIG:

120587350(CERS3)

PVP:	105290275(CERS3)

RAY:	107515791(CERS3)

MJV:	108386501(CERS3)

TOD:	119245188(CERS3)

SARA:

101550104(CERS3)

SETR:

126021837(CERS3)

LAV:	100671292(CERS3)

TMU:

101341813

ETF:	101653374(CERS3)

DNM:	101414521(CERS3)

MDO:	100020588(CERS3)

GAS:	123234193(CERS3)

SHR:	100919629(CERS3)

AFZ:

127551337

PCW:	110192586(CERS3)

TVP:	118830009(CERS3)

PBRV:

138169210(CERS3)

OAA:	100090484(CERS3)

GGA:	426648(CERS3)

MGP:	104912889(CERS3)

CJO:	107318875(CERS3)

TPAI:

128075248(CERS3)

LMUT:

125698426(CERS3)

NMEL:

110403582(CERS3)

APLA:

101794409(CERS3)

ACYG:

106036468(CERS3)

CATA:

118251930(CERS3)

AFUL:

116493542(CERS3)

TGU:	100223140(CERS3)

LSR:	110482993(CERS3)

SCAN:

103816094(CERS3)

PMOA:

120509089(CERS3)

OTC:	121343550(CERS3)

PRUF:

121354481(CERS3)

GFR:	102036650(CERS3)

FAB:	101818464(CERS3)

OMA:	130257364(CERS3)

PHI:	102104999(CERS3)

PMAJ:

107209495(CERS3)

CCAE:

111934002(CERS3)

CCW:	104683905(CERS3)

CBRC:

103619239(CERS3)

ACOE:

138116245(CERS3)

ETL:	114068286(CERS3)

ZAB:	102070635(CERS3)

ZLE:	135452174(CERS3)

ACHL:

103806343(CERS3)

SVG:	106852186(CERS3)

HRT:	120758786(CERS3)

SATI:

136366945(CERS3)

FPG:	101915529(CERS3)

FCH:	102054381(CERS3)

CCRI:

104163289(CERS3)

NNT:	104407072(CERS3)

SHAB:

115612772(CERS3)

ACUN:

113484146(CERS3)

TALA:

104368379(CERS3)

ACHC:

115341326(CERS3)

HALD:

104317589(CERS3)

HLE:	104834583(CERS3)

AGEN:

126043385

HHAR:

128150596(CERS3)

GCL:

127020695

CSTI:

104562225(CERS3)

LDI:	104351475(CERS3)

MNB:	103770554(CERS3)

DPUB:

104299712(CERS3)

PPUS:

135183140(CERS3)

AVIT:

104269993(CERS3)

BRHI:

104496347(CERS3)

EGZ:	104122870(CERS3)

NNI:	104017067(CERS3)

PCRI:

104028856(CERS3)

PCAO:

104046209(CERS3)

PADL:

103914771(CERS3)

AFOR:

103907329(CERS3)

FGA:	104079146(CERS3)

GSTE:

104257033(CERS3)

CLV:	102090020(CERS3)

MUI:	104541394(CERS3)

PGUU:

104472433(CERS3)

PLET:

104617867(CERS3)

EHS:	104516365(CERS3)

CMAC:

104475655(CERS3)

CUCA:

104062938(CERS3)

TEO:	104383570(CERS3)

BREG:

104630611(CERS3)

OHA:	104339289(CERS3)

ACAR:

104524379(CERS3)

CPEA:

104386699(CERS3)

CVF:	104288238(CERS3)

RTD:	128914661(CERS3)

AAM:	106495821(CERS3)

AROW:

112969803(CERS3)

NPD:	112948296(CERS3)

TGT:	104568858(CERS3)

DNE:	112996295(CERS3)

SCAM:

104148166(CERS3)

ASN:	102388749(CERS3)

AMJ:	102575439(CERS3)

CPOO:

109309161(CERS3)

GGN:	109288466(CERS3)

PSS:	102452581(CERS3)

CMY:	102939917(CERS3)

CCAY:

125643716(CERS3)

DCC:	119862540(CERS3)

CPIC:

101947682(CERS3)

TST:	117884533(CERS3)

CABI:

116816623(CERS3)

MRV:	120373108(CERS3)

ACS:	100554835(cers3)

ASAO:

132762562(CERS3)

PVT:	110072978(CERS3)

SUND:

121934958(CERS3)

PBI:	103067220(CERS3)

PMUR:

107283879(CERS3)

CTIG:

120315251(CERS3)

PGUT:

117669869(CERS3)

APRI:

131184918(CERS3)

PTEX:

113441996(CERS3)

NSS:	113415553(CERS3)

VKO:	123030808(CERS3)

PMUA:

114584561

ZVI:	118092579(CERS3)

HCG:	128334716(CERS3)

GJA:

107107422

STOW:

125424565(CERS3)

EMC:	129345544(CERS3)

XLA:	379135(cers3.L) 444162(cers3.S)

XTR:	448139(cers3)

NPR:	108790075(CERS3)

RTEM:

120931148(CERS3)

BBUF:

120985986(CERS3)

BGAR:

122923564 122927517(CERS3)

MUO:	115459908(CERS3)

GSH:	117348292(CERS3)

DRE:	100141367(cers3b) 100332380(cers3a)

SRX:	107719675 107733272 107742325

SANH:

107662258 107662883 107686553 107692405

SGH:	107553816 107559674 107562918

CCAR:

109052074 109087142 109109440

CAUA:

113051920 113052001 113100321 113105753 113118158

CGIB:

127933777 127962031 127976940 128017385

PTET:

122348536(cers3a) 122362568(cers3b)

LROH:

127167976(cers3a) 127180680(cers3b)

OMC:	131524944(cers3b)

PPRM:

120464869(cers3b) 120480136(cers3a)

RKG:	130071289(cers3b) 130074049(cers3a)

MAMB:

125254131(cers3b) 125264462(cers3a)

CIDE:

127500170 127516724

CERY:

137023221(cers3b) 137030872(cers3a)

MASI:

127456274

TROS:

130552865(cers3a) 130563292(cers3b)

TDW:	130413452(cers3a) 130435287(cers3b)

MANU:

129419537(cers3b) 129430172(cers3a)

IPU:	108264168(cers3b) 108271085(cers3a)

IFU:	128606364(cers3b) 128614005(cers3a)

PHYP:

113526340 113536588(cers3)

SMEO:

124391432(cers3a) 124395980(cers3b)

TFD:	113649636(cers3b) 113652894(cers3a)

TVC:	132851771(cers3b) 132855313(cers3a)

TRN:	134323090(cers3b) 134331551(cers3a)

AMEX:

103027875(cers3a) 103029792(cers3b)

CMAO:

118818105(cers3b) 118818889(cers3a)

EEE:	113573945(cers3) 113580530

CHAR:

105891127(cers3a)

TRU:

101066117

TFS:	130536130(cers3b)

TNG:	GSTEN00035593G001

LCO:	104929719(cers3) 104935212

NCC:

104957244

TBEN:

117480207(cers3a) 117491732(cers3b)

CGOB:

115004452 115009955

PGEO:

117440476(cers3a) 117447706(cers3b)

GACU:

117550147(cers3a) 117557662(cers3b)

EMAC:

134863523(cers3a) 134881627(cers3b)

ELY:	117255921(cers3a) 117261833(cers3b)

EFO:	125887456(cers3b) 125905346(cers3a)

PLEP:

121944372(cers3a) 121950432(cers3b)

SLUC:

116045176(cers3a) 116045667(cers3b)

ECRA:

117947619(cers3a) 117948874(cers3b)

ESP:	116684187 116694253(cers3) 116702387

PFLV:

114554884 114560654

GAT:	120809008(cers3b)

PPUG:

119196632(cers3b)

AFB:	129102735 129108617(cers3b)

CLUM:

117728780(cers3a)

PSWI:

130193209(cers3a)

CANA:

137803265(cers3a) 137804170(cers3b)

CVE:	137881326(cers3b)

MSAM:

119883380(cers3a) 119901488

SCHU:

122873190(cers3a) 122875282(cers3b)

CUD:	121510734(cers3a) 121515377(cers3b)

ALAT:

119018717(cers3a) 119025088

ASTR:

137594229(cers3b)

MZE:	101477435(cers3) 101480781

ONL:	100710960 100711452

OAU:	116313518(cers3b) 116320058(cers3a)

OLA:

111947541

OML:	112151761(cers3b)

CSAI:

133444760(cers3b) 133457048(cers3a)

XMA:	102234103 102236156

XCO:	114143780 114160349

XHE:	116708311 116718874

PRET:

103462267 103466657

PFOR:

103133806 103149196(cers3)

PLAI:

106956231 106959127(cers3)

PMEI:

106915516 106925757(cers3)

GAF:	122835013(cers3b) 122846287(cers3a)

PPRL:

129365265(cers3b)

CVG:	107096435 107102400

CTUL:

119773704(cers3a)

GMU:	124866838(cers3a) 124877958(cers3b)

NFU:

107388829

KMR:	108229836(cers3b) 108250391(cers3a)

ALIM:

106514312(cers3)

NWH:	119416282(cers3b) 119429828(cers3a)

AOCE:

111571929 111581063

EJA:	138206227(cers3b) 138212520(cers3a)

MCEP:

125005721(cers3a) 125014337(cers3b)

CSEM:

103378927(cers3)

POV:	109623996 109624784(cers3)

SSEN:

122772881(cers3a) 122775403(cers3b)

HHIP:

117759513(cers3a) 117763801(cers3b)

HSP:	118109828(cers3b) 118112445(cers3a)

PPLT:

128442043(cers3a) 128444596

SMAU:

118302196(cers3a) 118315359(cers3b)

LCF:	108875121(cers3b) 108894327(cers3a)

SDU:	111220178(cers3) 111228613

SLAL:

111644372 111653318

XGL:	120793324(cers3b) 120796400(cers3a)

HCQ:

109528089

SSCV:

125971080(cers3b)

SBIA:

133501771(cers3b)

PEE:	133402722(cers3b)

PTAO:

133478293(cers3b)

BPEC:

110162568 110169205

MALB:

109951998 109967919

BSPL:

114857840(cers3b)

SJO:	128359424(cers3b) 128363521(cers3a)

SASA:

106562479 106562576

STRU:

115166866 115203458

OTW:	112241699(cers3a)

OMY:	110506178 110517996

OGO:	124035401 124035507(cers3a)

ONE:

115125322

OKI:

109886548

OKE:

118375141

SNH:	120057070(cers3a)

CCLU:

121548345 123481019

ELS:	105014426(cers3)

SFM:	108941195(cers3)

PKI:	111845096(cers3)

AANG:

118215161 118227406(cers3a)

LOC:	102694534(cers3)

PSPA:

121295084(cers3a) 121299274

ARUT:

117427980 117429295

CPLA:

122541102(cers3a)

ESN:

HAZT:

BGT:

MMER:

Reference

PMID:16753040

Authors

Mizutani Y, Kihara A, Igarashi Y

Title

LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.

Journal

Biochem J 398:531-8 (2006)
DOI:10.1042/BJ20060379

Sequence

[mmu:545975]

LinkDB

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