KEGG ORTHOLOGY: K24812

ORTHOLOGY: K24812

Entry

K24812                      KO

Symbol

HEATR3

Name

HEAT repeat-containing protein 3

Disease

H00237

Diamond-Blackfan anemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K24812  HEATR3; HEAT repeat-containing protein 3
Domain-containing proteins not elsewhere classified [BR:ko04990]
Other domain-containing proteins
  HEAT repeat domain-containing proteins
   K24812  HEATR3; HEAT repeat-containing protein 3

Genes

HSA:	55027(HEATR3)

PTR:	465159(HEATR3)

PPS:	100977026(HEATR3)

GGO:	101133024(HEATR3)

PON:	100447333(HEATR3)

PPYG:

129015309(HEATR3)

NLE:	100586375(HEATR3)

HMH:	116471244(HEATR3)

SSYN:

129492498(HEATR3)

MCC:	696428(HEATR3)

MCF:	102123778(HEATR3)

MTHB:

126944922

MNI:	105492249(HEATR3)

CSAB:

103232639(HEATR3)

CATY:

105588975(HEATR3)

PANU:

100997923(HEATR3)

TGE:	112614811(HEATR3)

MLEU:

105546060(HEATR3)

RRO:	104672894(HEATR3)

TFN:	117088594(HEATR3)

CANG:

105514967(HEATR3)

CJC:	100413528(HEATR3)

SBQ:	101030992(HEATR3)

CIMI:

108305482(HEATR3)

ANAN:

105730807(HEATR3)

CSYR:

103259331(HEATR3)

MMUR:

105884748(HEATR3)

LCAT:

123624985(HEATR3)

PCOQ:

105808850(HEATR3)

OGA:	100956608(HEATR3)

MMU:	234549(Heatr3)

MCAL:

110299826(Heatr3)

RNO:	361375(Heatr3)

MCOC:

116069814(Heatr3)

ANU:	117723219(Heatr3)

ASYL:

127671716(Heatr3)

MUN:	110560699(Heatr3)

CGE:	100756422(Heatr3)

MAUA:

101840392(Heatr3)

PROB:

127229975(Heatr3)

PLEU:

114700537 114708492(Heatr3)

MORG:

121447435(Heatr3)

MFOT:

126487135

AAMP:

119802131(Heatr3)

NGI:	103730117(Heatr3)

HGL:	101713807(Heatr3)

CPOC:

100726430(Heatr3)

CCAN:

109696621(Heatr3)

DORD:

105994402(Heatr3)

DSP:	122119377(Heatr3)

PLOP:

125358484(Heatr3)

NCAR:

124967087

MMMA:

107144881(Heatr3)

ITI:	101965096(Heatr3)

OCU:

100357872

OPI:	101517813(HEATR3)

TUP:	102488135(HEATR3)

GVR:	103594836(HEATR3)

CFA:	478132(HEATR3)

CLUD:

112660004(HEATR3)

VVP:	112929601(HEATR3)

VLG:	121498082(HEATR3)

NPO:	129513491(HEATR3)

AML:	100466464(HEATR3)

UMR:	103673802(HEATR3)

UAH:	113252220(HEATR3)

UAR:	123798390(HEATR3)

ELK:

111157391

LLV:

125089492

MPUF:

101682531(HEATR3)

MNP:	132004912(HEATR3)

MLK:	131817535(HEATR3)

NVS:	122911466(HEATR3)

ORO:	101376246(HEATR3)

EJU:	114201714(HEATR3)

ZCA:	113936494(HEATR3)

MLX:	118023804(HEATR3)

NSU:	110594285(HEATR3)

LWW:	102730622(HEATR3)

FCA:	101095868(HEATR3)

PYU:	121045269(HEATR3)

PCOO:

112857211(HEATR3)

PBG:	122494181(HEATR3)

PVIV:

125153060(HEATR3)

LRUF:

124511304

LGF:	123579122(HEATR3)

AJU:

106985848

PTG:	102948611(HEATR3)

PPAD:

109270957(HEATR3)

PUC:

125915728

PLEZ:

122208029(HEATR3)

HHV:	120238532(HEATR3)

BTA:	539353(HEATR3)

BOM:	102267714(HEATR3)

BIU:	109572685(HEATR3)

BBUB:

102408596(HEATR3)

BBIS:

104999541(HEATR3)

CHX:	102185593(HEATR3)

OAS:	101112412(HEATR3)

BTAX:

128063277(HEATR3)

CSUM:

138096287(HEATR3)

ODA:	120872815(HEATR3)

CCAD:

122420973(HEATR3)

MREE:

136160965(HEATR3)

OVR:	110148095(HEATR3)

MBEZ:

129547121(HEATR3)

SSC:	110260964(HEATR3)

CFR:	102506740(HEATR3)

CBAI:

105074274(HEATR3)

CDK:	105097531(HEATR3)

VPC:	102530210(HEATR3)

BACU:

102999570(HEATR3)

BMUS:

118885247(HEATR3)

LVE:	103079222(HEATR3)

OOR:	101270183(HEATR3)

LALB:

132509570(HEATR3)

DLE:	111165002(HEATR3)

PCAD:

102982803(HEATR3)

PSIU:

116744270(HEATR3)

NASI:

112401286(HEATR3)

ECB:	100058410(HEATR3)

EPZ:	103548993(HEATR3)

EAI:	106824128(HEATR3)

MYB:	102253857(HEATR3)

MYD:	102763762(HEATR3)

MMYO:

118674438(HEATR3)

MLF:	102425333(HEATR3)

MDT:	132217598(HEATR3)

MYUM:

138996943(HEATR3)

PKL:	118720581(HEATR3)

EFUS:

103295864(HEATR3)

MNA:	107531020(HEATR3)

DRO:	112296688(HEATR3)

SHON:

119001140(HEATR3)

AJM:	119046472(HEATR3)

PDIC:

114488283(HEATR3)

PHAS:

123806058(HEATR3)

MMF:	118639484(HEATR3)

PPAM:

129068202(HEATR3)

HAI:	109383240(HEATR3)

RFQ:	117034782(HEATR3)

PALE:

102880840(HEATR3)

PGIG:

120617383(HEATR3)

PVP:	105292088(HEATR3)

RAY:	107512252(HEATR3)

MJV:	108403154(HEATR3)

TOD:	119249162(HEATR3)

SARA:

101544117(HEATR3)

SFUM:

130044392(HEATR3)

SETR:

126027089(HEATR3)

LAV:	100673501(HEATR3)

TMU:

101347645

ETF:	101640901(HEATR3)

DNM:	101424976(HEATR3)

MDO:	100017877(HEATR3)

GAS:	123237316(HEATR3)

SHR:	100913211(HEATR3)

AFZ:

127550693

PCW:	110207470(HEATR3)

TVP:	118844859(HEATR3)

PBRV:

138157073(HEATR3)

OAA:	100076144(HEATR3)

TACU:

119933997(HEATR3)

GGA:	415734(HEATR3)

PCOC:

116243728(HEATR3)

MGP:

100549224

CJO:	107319022(HEATR3)

TPAI:

128082549(HEATR3)

LMUT:

125699140(HEATR3)

NMEL:

110404377(HEATR3)

APLA:

101803872(HEATR3)

ACYG:

106039617(HEATR3)

CATA:

118246349(HEATR3)

AFUL:

116493913(HEATR3)

TGU:	100232457(HEATR3)

LSR:	110473533(HEATR3)

SCAN:

103816618(HEATR3)

PMOA:

120507941(HEATR3)

OTC:	121333783(HEATR3)

PRUF:

121348757(HEATR3)

ATRC:

139596259(HEATR3)

GFR:	102041012(HEATR3)

FAB:	101816521(HEATR3)

OMA:	130257735(HEATR3)

PHI:	102109666(HEATR3)

PMAJ:

107209896(HEATR3)

CCAE:

111934613(HEATR3)

CCW:	104687451(HEATR3)

CBRC:

103620197(HEATR3)

ACOE:

138117217(HEATR3)

ETL:	114055555(HEATR3)

ZAB:	102063595(HEATR3)

ZLE:	135452569(HEATR3)

ACHL:

103808809(HEATR3)

SVG:	106856979(HEATR3)

MMEA:

130579122(HEATR3)

HRT:	120757608(HEATR3)

SATI:

136366654(HEATR3)

CCIC:

134048181(HEATR3)

FPG:	101914266(HEATR3)

FCH:	102052394(HEATR3)

CCRI:

104162459(HEATR3)

NNT:	104399715(HEATR3)

SHAB:

115619608(HEATR3)

ACUN:

113484281(HEATR3)

TALA:

104355862(HEATR3)

ACHC:

115345321(HEATR3)

HALD:

104311317(HEATR3)

HLE:	104842587(HEATR3)

AGEN:

126041381

HHAR:

128145619(HEATR3)

GCL:

127020941

CSTI:

104556943(HEATR3)

LDI:	104340566(HEATR3)

MNB:	103780625(HEATR3)

DPUB:

104303143(HEATR3)

PPUS:

135184506(HEATR3)

BRHI:

104502084(HEATR3)

EGZ:	104125188(HEATR3)

NNI:	104011270(HEATR3)

PCRI:

104024601(HEATR3)

PCAO:

104039847(HEATR3)

PADL:

103913757(HEATR3)

AFOR:

103896806(HEATR3)

FGA:	104075311(HEATR3)

GSTE:

104251147(HEATR3)

CBOY:

140656329(HEATR3)

CLV:	102097153(HEATR3)

MUI:	104533954(HEATR3)

PGUU:

104457608(HEATR3)

PLET:

104614404(HEATR3)

EHS:	104503559(HEATR3)

CMAC:

104473791(HEATR3)

CUCA:

104068342(HEATR3)

TEO:	104381658(HEATR3)

BREG:

104629866(HEATR3)

OHA:	104338972(HEATR3)

ACAR:

104522684(HEATR3)

CPEA:

104388573(HEATR3)

CVF:	104286474(HEATR3)

RTD:	128908488(HEATR3)

CRID:

134515426(HEATR3)

AAM:	106483205(HEATR3)

AROW:

112967560(HEATR3)

NPD:	112944954(HEATR3)

TGT:	104566598(HEATR3)

DNE:	112984383(HEATR3)

SCAM:

104146328(HEATR3)

ASN:	102369234(HEATR3)

AMJ:	102563292(HEATR3)

CPOO:

109310537(HEATR3)

GGN:	109289589(HEATR3)

PSS:	102450159(HEATR3)

CMY:	102945780(HEATR3)

CCAY:

125620624(HEATR3)

DCC:	119841079(HEATR3)

CPIC:

101950756(HEATR3)

TST:	117886680(HEATR3)

CABI:

116826972(HEATR3)

MRV:	120384510(HEATR3)

ACS:	100560525(heatr3)

ASAO:

132783202(HEATR3)

PVT:	110086574(HEATR3)

SUND:

121914216(HEATR3)

PBI:	103067184(HEATR3)

PMUR:

107290056(HEATR3)

CTIG:

120312121(HEATR3)

TSR:	106548996(HEATR3)

PGUT:

117670933(HEATR3)

APRI:

131183995(HEATR3)

PTEX:

113444971(HEATR3)

VKO:	123022302(HEATR3)

PMUA:

114602232(HEATR3)

PRAF:

128419467(HEATR3)

ZVI:	118087719(HEATR3)

HCG:	128334457(HEATR3)

GJA:	107117187(HEATR3)

STOW:

125443598(HEATR3)

EMC:	129344044(HEATR3)

XLA:

108713990

XTR:	496925(heatr3)

NPR:	108794660(HEATR3)

RTEM:

120917432(HEATR3)

BBUF:

120980611(HEATR3)

BGAR:

122920304(HEATR3)

PWL:	138268717(HEATR3)

MUO:	115470806(HEATR3)

GSH:	117354680 117354687 117359259

DRE:	393863(heatr3)

SRX:	107722414 107758777

SANH:

107657125 107696712

SGH:	107551471 107554609(heatr3)

CCAR:

109084829 109093259

CAUA:

113051422 113106063

CGIB:

127962590 128016843

PTET:

122349735(heatr3)

LROH:

127168878(heatr3)

OMC:	131544780(heatr3)

PPRM:

120468762(heatr3)

RKG:	130069736(heatr3)

MAMB:

125265056(heatr3)

CIDE:

127515462

CERY:

137030401(heatr3)

MASI:

127414198 127444121

TROS:

130562876(heatr3)

TDW:	130429453(heatr3)

MANU:

129444890(heatr3)

PDAB:

135778888(heatr3)

IPU:

108259216

IFU:	128602848(heatr3)

PHYP:

113540844(heatr3)

SMEO:

124380188(heatr3)

TFD:	113656371(heatr3)

TVC:	132838882(heatr3)

CGAR:

128518293(heatr3)

NGRA:

132875167(heatr3)

TRN:	134304290(heatr3)

AMEX:

103046440(heatr3)

CMAO:

118817522(heatr3)

EEE:	113592066(heatr3)

CHAR:

105893112(heatr3)

SPIL:

134069350(heatr3)

TRU:	101070986(heatr3)

TFS:	130521881(heatr3)

LCO:	104920776(heatr3)

TBEN:

117496711(heatr3)

CGOB:

115006457(heatr3)

PGEO:

117441185(heatr3)

GACU:

117549055(heatr3)

EMAC:

134862511(heatr3)

ELY:	117260533(heatr3)

EFO:	125878907(heatr3)

PLEP:

121939661(heatr3)

SLUC:

116037574(heatr3)

ECRA:

117952377(heatr3)

ESP:	116689618(heatr3)

PFLV:

114559198(heatr3)

GAT:	120811643(heatr3)

PPUG:

119225256(heatr3)

AFB:	129103064(heatr3)

CLUM:

117728681(heatr3)

PSWI:

130192881(heatr3)

CANA:

137783336(heatr3)

CVE:	137887832(heatr3)

MSAM:

119890091(heatr3)

SCHU:

122864223(heatr3)

CUD:	121514502(heatr3)

SPUL:

138588766(heatr3)

LMIX:

132979828(heatr3)

ALAT:

119018468(heatr3)

ASTR:

137593979(heatr3)

MZE:	101481003(heatr3)

ONL:	100703765(heatr3)

OAU:	116325580(heatr3)

OLA:	101165220(heatr3)

OML:	112160722(heatr3)

CSAI:

133421483(heatr3)

XMA:	102230250(heatr3)

XCO:	114143238(heatr3)

XHE:	116718810(heatr3)

PRET:

103462643(heatr3)

PFOR:

103138065(heatr3)

PLAI:

106957720(heatr3)

PMEI:

106927341(heatr3)

GAF:	122825254(heatr3)

PPRL:

129364420(heatr3)

CVG:	107088491(heatr3)

CTUL:

119781963(heatr3)

GMU:	124866467(heatr3)

NFU:	107382080(heatr3)

KMR:	108243340(heatr3)

ALIM:

106527046(heatr3)

NWH:	119426415(heatr3)

AOCE:

111572261(heatr3)

EJA:	138213265(heatr3)

BFRE:

138616227(heatr3)

MCEP:

125005162(heatr3)

CSEM:

103379339(heatr3)

POV:	109625146(heatr3)

SSEN:

122772326(heatr3)

SSOE:

131459400(heatr3)

HHIP:

117759594(heatr3)

HSP:	118110866(heatr3)

PPLT:

128441795(heatr3)

SMAU:

118301965(heatr3)

LCF:

108877038

SDU:	111217686(heatr3)

SLAL:

111672245(heatr3)

XGL:	120793784(heatr3)

HCQ:	109513985(heatr3)

SSCV:

125966815(heatr3)

SBIA:

133498171(heatr3)

PEE:	133397849(heatr3)

PTAO:

133474149(heatr3)

BPEC:

110175292(heatr3)

ENY:	140381304(heatr3)

MALB:

109955855(heatr3)

BSPL:

114852642(heatr3)

SJO:	128356514(heatr3)

SSCO:

134004821(heatr3)

GMH:	115558825(heatr3)

SASA:

106562380 106587571

STRU:

115167036 115203283

OTW:	112249335 112249336

OMY:	110506727 110526591(heatr3)

OGO:	124033590 124035568

ONE:	115112483 115113764

OKI:	109881360 109881659

OKE:	118360746 118382101

OMM:	135550921 135557359

OCLA:

139385023 139411598

SALP:

111969535 111974602

SNH:	120024982 120056559

CCLU:

121535802 123487134

ELS:	105025702(heatr3)

OEP:	134028056(heatr3)

SFM:	108932936(heatr3)

PKI:	111832737(heatr3)

AANG:

118228450(heatr3)

AROT:

135255063(heatr3)

CCOG:

133130897(heatr3)

LOC:	102687112(heatr3)

PSPA:

121296383 121325898

ARUT:

117424252 117425660

PSEX:

120535201(heatr3)

LCM:	102354943(HEATR3)

CMK:	103176078(heatr3)

RTP:	109914194(heatr3)

CPLA:

122558408(heatr3)

HOC:	132823722(heatr3)

LERI:

129705027(heatr3)

PMRN:

116956039(HEATR3)

LRJ:	133357894(HEATR3)

BFO:

BBEL:

SPU:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG10286(CG10286)

DER:

6553251

DSE:

6614107

DSI:	Dsimw501_GD19870(Dsim_GD19870)

DYA:	Dyak_GE10216

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:	119644009 119644010

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ001806

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

LHT:

LBD:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

BMOR:

MSEX:

DPL:	KGM_203795

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

BTAB:

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

PAME:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_224137

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_229792

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

Reference

PMID:23615072

Authors

Zhang W, Hui KY, Gusev A, Warner N, Ng SM, Ferguson J, Choi M, Burberry A, Abraham C, Mayer L, Desnick RJ, Cardinale CJ, Hakonarson H, Waterman M, Chowers Y, Karban A, Brant SR, Silverberg MS, Gregersen PK, Katz S, Lifton RP, Zhao H, Nunez G, Pe'er I, Peter I, Cho JH

Title

Extended haplotype association study in Crohn's disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-kappaB pathway gene, HEATR3.

Journal

Genes Immun 14:310-6 (2013)
DOI:10.1038/gene.2013.19

Sequence

[hsa:55027]

LinkDB

DBGET integrated database retrieval system