KEGG   ORTHOLOGY: K25261
Entry
K25261                      KO                                     
Symbol
islA
Name
isethionate sulfite-lyase [EC:4.4.1.38]
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Reaction
R12763  isethionate sulfite-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K25261  islA; isethionate sulfite-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.38  isethionate sulfite-lyase
     K25261  islA; isethionate sulfite-lyase
Other DBs
COG: COG1882
Genes
PWA: Pecwa_3461
PPAR: A8F97_01320
PEC: W5S_3597
PWS: A7983_13280
PCAC: OI450_00875
BGJ: AWC36_05935
BNG: EH206_07475
BIZ: HC231_15860
SLIG: GTU79_10120
DDS: Ddes_1436
DFI: AXF13_05515
DPG: DESPIGER_1590
DEF: CNY67_06110
DDE: Dde_1273
DPI: BN4_11150
PPRF: DPRO_3546
PTHE: LF599_13280
PBIZ: LWC08_09755
DVU: DVU_2824
DVL: Dvul_0491
DVG: Deval_2606
CLIH: KPS_000048
DBA: Dbac_1587
DESU: NLA06_05930
DPS: DP3027
DEO: CAY53_09700
PBD: PBOR_26450
CPAS: Clopa_0943
DSY: DSY0416
DHD: Dhaf_0366
DDH: Desde_0364
DRM: Dred_2750
DRU: Desru_0475
DFG: B0537_01450
DKU: Desku_2520
ABUT: Ami103574_01305
MANA: MAMMFC1_01805(bssA_1) MAMMFC1_01806(bssA_2)
STED: SPTER_02740(cutC_1) SPTER_04740(cutC_2)
LUB: TBR22_A12620
 » show all
Reference
PMID:30962433
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2824]
LinkDB

KEGG   ORTHOLOGY: K25262
Entry
K25262                      KO                                     
Symbol
islB
Name
isethionate sulfite-lyase activating enzyme
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Reaction
R12763  isethionate sulfite-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K25262  islB; isethionate sulfite-lyase activating enzyme
Other DBs
COG: COG1180 COG1145
Genes
PWA: Pecwa_3460
PPAR: A8F97_01325
PEC: W5S_3596
PWS: A7983_13285
PCAC: OI450_00880
BGJ: AWC36_05940
BNG: EH206_07480
BIZ: HC231_14355 HC231_15855
RLAC: QMO75_05485
DDS: Ddes_1435
DFI: AXF13_05520
DPG: DESPIGER_1589
DEF: CNY67_06115
DDE: Dde_1272
DPI: BN4_11149(pflC)
PPRF: DPRO_3547(pflC)
PTHE: LF599_13275
PBIZ: LWC08_09750
DVU: DVU_2825
DVL: Dvul_0490
DVG: Deval_2607
CLIH: KPS_000047
DBA: Dbac_1586
DESU: NLA06_05935
DPS: DP3026(pflC)
DEO: CAY53_09695
PBD: PBOR_26445
CPAS: Clopa_0944
AMUR: ADH66_08105
DSY: DSY0417
DHD: Dhaf_0367
DDH: Desde_0365
DRM: Dred_2752
DRU: Desru_0476
DFG: B0537_01455
DKU: Desku_2519
ABUT: Ami103574_01310
NCD: ACONDI_00249(bssD_1)
MANA: MAMMFC1_01807(bssD_1)
STED: SPTER_02750(csdA) SPTER_04750(cutD_1)
LUB: TBR22_A12540
 » show all
Reference
PMID:30962433
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2825]
LinkDB

KEGG   ENZYME: 4.4.1.38
Entry
EC 4.4.1.38                 Enzyme                                 
Name
isethionate sulfite-lyase;
islA (gene name)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
isethionate sulfite-lyase
Reaction(IUBMB)
isethionate = acetaldehyde + sulfite [RN:R12763]
Reaction(KEGG)
R12763
Substrate
isethionate [CPD:C05123]
Product
acetaldehyde [CPD:C00084];
sulfite [CPD:C00094]
Comment
The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.
History
EC 4.4.1.38 created 2021
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K25261  isethionate sulfite-lyase
Genes
PWA: Pecwa_3461
PPAR: A8F97_01320
PEC: W5S_3597
PWS: A7983_13280
PCAC: OI450_00875
BGJ: AWC36_05935
BNG: EH206_07475
BIZ: HC231_15860
SLIG: GTU79_10120
DDS: Ddes_1436
DFI: AXF13_05515
DPG: DESPIGER_1590
DEF: CNY67_06110
DDE: Dde_1273
DPI: BN4_11150
PPRF: DPRO_3546
PTHE: LF599_13280
PBIZ: LWC08_09755
DVU: DVU_2824
DVL: Dvul_0491
DVG: Deval_2606
CLIH: KPS_000048
DBA: Dbac_1587
DESU: NLA06_05930
DPS: DP3027
DEO: CAY53_09700
PBD: PBOR_26450
CPAS: Clopa_0943
DSY: DSY0416
DHD: Dhaf_0366
DDH: Desde_0364
DRM: Dred_2750
DRU: Desru_0475
DFG: B0537_01450
DKU: Desku_2520
ABUT: Ami103574_01305
MANA: MAMMFC1_01805(bssA_1) MAMMFC1_01806(bssA_2)
STED: SPTER_02740(cutC_1) SPTER_04740(cutC_2)
LUB: TBR22_A12620
 » show all
Reference
1  [PMID:30718429]
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
Reference
2  [PMID:30962433]
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2824]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.38
IUBMB Enzyme Nomenclature: 4.4.1.38
ExPASy - ENZYME nomenclature database: 4.4.1.38
BRENDA, the Enzyme Database: 4.4.1.38
LinkDB

KEGG   REACTION: R12763
Entry
R12763                      Reaction                               
Name
isethionate sulfite-lyase
Definition
2-Hydroxyethanesulfonate <=> Acetaldehyde + Sulfite
Equation
C05123 <=> C00084 + C00094
Enzyme
4.4.1.38
Pathway
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.38
     R12763  2-Hydroxyethanesulfonate <=> Acetaldehyde + Sulfite
Orthology
K25261  isethionate sulfite-lyase [EC:4.4.1.38]
K25262  isethionate sulfite-lyase activating enzyme
Other DBs
RHEA: 60455
LinkDB

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