KEGG   ORTHOLOGY: K25261
Entry
K25261                      KO                                     

Symbol
islA
Name
isethionate sulfite-lyase [EC:4.4.1.38]
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K25261  islA; isethionate sulfite-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.38  isethionate sulfite-lyase
     K25261  islA; isethionate sulfite-lyase
Other DBs
RN: R12763
COG: COG1882
Genes
PWA: Pecwa_3461
PPAR: A8F97_01320
PEC: W5S_3597
PWS: A7983_13280
BGJ: AWC36_05935
BNG: EH206_07475
BIZ: HC231_15860
DVU: DVU_2824
DVL: Dvul_0491
DVG: Deval_2606
DDE: Dde_1273
DDS: Ddes_1436
DPI: BN4_11150
PPRF: DPRO_3546
DBA: Dbac_1587
DPS: DP3027
CPAS: Clopa_0943
DSY: DSY0416
DHD: Dhaf_0366
DRM: Dred_2750
MANA: MAMMFC1_01805(bssA_1) MAMMFC1_01806(bssA_2)
STED: SPTER_02740(cutC_1) SPTER_04740(cutC_2)
 » show all
Reference
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2824]
LinkDB

KEGG   ORTHOLOGY: K25262
Entry
K25262                      KO                                     

Symbol
islB
Name
isethionate sulfite-lyase activating enzyme
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K25262  islB; isethionate sulfite-lyase activating enzyme
Other DBs
RN: R12763
COG: COG1180 COG1145
Genes
PWA: Pecwa_3460
PPAR: A8F97_01325
PEC: W5S_3596
PWS: A7983_13285
BGJ: AWC36_05940
BNG: EH206_07480
BIZ: HC231_14355 HC231_15855
DVU: DVU_2825
DVL: Dvul_0490
DVG: Deval_2607
DDE: Dde_1272
DDS: Ddes_1435
DPI: BN4_11149(pflC)
PPRF: DPRO_3547(pflC)
DBA: Dbac_1586
DPS: DP3026(pflC)
CPAS: Clopa_0944
DSY: DSY0417
DHD: Dhaf_0367
DRM: Dred_2752
MANA: MAMMFC1_01807(bssD_1)
STED: SPTER_02750(csdA) SPTER_04750(cutD_1)
 » show all
Reference
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2825]
LinkDB

KEGG   ENZYME: 4.4.1.38
Entry
EC 4.4.1.38                 Enzyme                                 

Name
isethionate sulfite-lyase;
islA (gene name)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
isethionate sulfite-lyase
Reaction(IUBMB)
isethionate = acetaldehyde + sulfite [RN:R12763]
Reaction(KEGG)
R12763
Substrate
isethionate [CPD:C05123]
Product
acetaldehyde [CPD:C00084];
sulfite [CPD:C00094]
Comment
The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.
History
EC 4.4.1.38 created 2021
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K25261  isethionate sulfite-lyase
Genes
PWA: Pecwa_3461
PPAR: A8F97_01320
PEC: W5S_3597
PWS: A7983_13280
BGJ: AWC36_05935
BNG: EH206_07475
BIZ: HC231_15860
DVU: DVU_2824
DVL: Dvul_0491
DVG: Deval_2606
DDE: Dde_1273
DDS: Ddes_1436
DPI: BN4_11150
PPRF: DPRO_3546
DBA: Dbac_1587
DPS: DP3027
CPAS: Clopa_0943
DSY: DSY0416
DHD: Dhaf_0366
DRM: Dred_2750
MANA: MAMMFC1_01805(bssA_1) MAMMFC1_01806(bssA_2)
STED: SPTER_02740(cutC_1) SPTER_04740(cutC_2)
 » show all
Reference
1  [PMID:30718429]
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
Reference
2  [PMID:30962433]
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2824]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.38
IUBMB Enzyme Nomenclature: 4.4.1.38
ExPASy - ENZYME nomenclature database: 4.4.1.38
BRENDA, the Enzyme Database: 4.4.1.38
LinkDB

KEGG   REACTION: R12763
Entry
R12763                      Reaction                               

Name
isethionate sulfite-lyase
Definition
2-Hydroxyethanesulfonate <=> Acetaldehyde + Sulfite
Equation
Enzyme
Pathway
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Orthology
K25261  isethionate sulfite-lyase [EC:4.4.1.38]
K25262  isethionate sulfite-lyase activating enzyme
LinkDB

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