KEGG   ORTHOLOGY: K25985
Entry
K25985                      KO                                     
Symbol
sarD, tauF
Name
sulfoacetaldehyde reductase (NADH) [EC:1.1.1.433]
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Reaction
R13009  isethionate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K25985  sarD, tauF; sulfoacetaldehyde reductase (NADH)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.433  sulfoacetaldehyde reductase (NADH)
     K25985  sarD, tauF; sulfoacetaldehyde reductase (NADH)
Other DBs
COG: COG1454
Genes
APRL: PY247_20480
OAL: NB647_05325
DFI: AXF13_01465
DBA: Dbac_1584
DPS: DP0542 DP0546
DEO: CAY53_09715
BSM: BSM4216_2470
APAK: AP3564_07955
PASA: BAOM_1155(yiaY)
BAG: Bcoa_0947
STEA: C0679_03240
SHV: AAT16_10375
JEA: JEM45_10545
CPAS: Clopa_0949
CBUT: ATN24_00660
RPAY: P0092_15965
FPLA: A4U99_15655
INT: RX717_02205
BMAS: LK422_01770
RIL: CRIB_1603
BKA: AH68_00250
BEU: BE0216_06995
BSUE: BS3272_06430
MAEO: JRV97_03420
MJK: N2V74_07290
AG: EFV43471(sarD)
 » show all
Reference
PMID:30718429
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
  Sequence
[ag:EFV43471]
Reference
PMID:31123167
  Authors
Zhou Y, Wei Y, Nanjaraj Urs AN, Lin L, Xu T, Hu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense.
  Journal
Biosci Rep 39:BSR20190715 (2019)
DOI:10.1042/BSR20190715
  Sequence
[bka:AH68_00250]
LinkDB

KEGG   ENZYME: 1.1.1.433
Entry
EC 1.1.1.433                Enzyme                                 
Name
sulfoacetaldehyde reductase (NADH);
sarD (gene name);
tauF (gene name);
sqwF (gene name);
BkTauF
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
isethionate:NAD+ oxidoreductase
Reaction(IUBMB)
isethionate + NAD+ = 2-sulfoacetaldehyde + NADH + H+ [RN:R13009]
Reaction(KEGG)
R13009
Substrate
isethionate [CPD:C05123];
NAD+ [CPD:C00003]
Product
2-sulfoacetaldehyde [CPD:C00593];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from the bacteria Bilophila wadsworthia and Clostridium sp. MSTE9 catalyse the reaction only in the reduction direction. In the bacterium Bifidobacterium kashiwanohense the optimal reaction pH for sulfoacetaldehyde reduction is 7.5, while that for isethionate oxidation is 10.0. cf. EC 1.1.1.313, sulfoacetaldehyde reductase (NADPH).
History
EC 1.1.1.433 created 2022
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K25985  sulfoacetaldehyde reductase (NADH)
Genes
APRL: PY247_20480
OAL: NB647_05325
DFI: AXF13_01465
DBA: Dbac_1584
DPS: DP0542 DP0546
DEO: CAY53_09715
BSM: BSM4216_2470
APAK: AP3564_07955
PASA: BAOM_1155(yiaY)
BAG: Bcoa_0947
STEA: C0679_03240
SHV: AAT16_10375
JEA: JEM45_10545
CPAS: Clopa_0949
CBUT: ATN24_00660
RPAY: P0092_15965
FPLA: A4U99_15655
INT: RX717_02205
BMAS: LK422_01770
RIL: CRIB_1603
BKA: AH68_00250
BEU: BE0216_06995
BSUE: BS3272_06430
MAEO: JRV97_03420
MJK: N2V74_07290
 » show all
Reference
1  [PMID:30718429]
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
  Sequence
[ag:EFV43471]
Reference
2  [PMID:30962433]
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
Reference
3  [PMID:31123167]
  Authors
Zhou Y, Wei Y, Nanjaraj Urs AN, Lin L, Xu T, Hu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense.
  Journal
Biosci Rep 39:BSR20190715 (2019)
DOI:10.1042/BSR20190715
  Sequence
[bka:AH68_00250]
Reference
4
  Authors
Liu J, Wei Y, Ma K, An J, Liu X, Liu Y, Ang EL, Zhao H, Zhang Y.
  Title
Mechanistically diverse pathways for sulfoquinovose degradation in bacteria.
  Journal
ACS Catal 11:14740-14750 (2021)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.433
IUBMB Enzyme Nomenclature: 1.1.1.433
ExPASy - ENZYME nomenclature database: 1.1.1.433
BRENDA, the Enzyme Database: 1.1.1.433
LinkDB

KEGG   REACTION: R13009
Entry
R13009                      Reaction                               
Name
isethionate:NAD+ oxidoreductase
Definition
2-Hydroxyethanesulfonate + NAD+ <=> Sulfoacetaldehyde + NADH + H+
Equation
C05123 + C00003 <=> C00593 + C00004 + C00080
Comment
NADPH (see R02600)
Reaction class
RC00087  C00593_C05123
Enzyme
1.1.1.433
Pathway
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.433
     R13009  2-Hydroxyethanesulfonate + NAD+ <=> Sulfoacetaldehyde + NADH + H+
Orthology
K25985  sulfoacetaldehyde reductase (NADH) [EC:1.1.1.433]
LinkDB

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