KEGG ORTHOLOGY: K27070

ORTHOLOGY: K27070

Entry

K27070                      KO

Symbol

kasB

Name

meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC:2.3.1.294]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Reaction

R13270

ultra-long-chain-di-unsaturated-acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27070  kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K27070  kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.294  meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II
     K27070  kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K27070  kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II

Other DBs

COG:

COG0304

Genes

MTU:	Rv2246(kasB)

MTV:

RVBD_2246

MTC:	MT2306(fabF-2)

MRA:	MRA_2266(kasB)

MTF:	TBFG_12275

MTB:	TBMG_01734

MTK:	TBSG_01744

MTZ:	TBXG_001716

MTI:	MRGA423_13985

MTE:	CCDC5079_2083

MTUR:

CFBS_2379(kasB)

MTL:	CCDC5180_2055

MTO:	MTCTRI2_2282(kasB)

MTD:	UDA_2246(kasB)

MTN:	ERDMAN_2471(kasB)

MTJ:	J112_12060

MTUB:

MT7199_2278

MTUE:

J114_12040

MTX:	M943_11635

MTUL:

TBHG_02198

MTUT:

HKBT1_2370(kasB)

MTUU:

HKBT2_2372(kasB)

MTQ:	HKBS1_2376(kasB)

MBO:	BQ2027_MB2270(kasB)

MBB:	BCG_2263(kasB)

MBT:	JTY_2257(kasB)

MBM:	BCGMEX_2251(kasB)

MBK:	K60_023310

MBX:

BCGT_2069

MAF:	MAF_22570(kasB)

MMIC:

RN08_2494

MCE:	MCAN_22681(kasB)

MCQ:	BN44_50189(kasB)

MCV:	BN43_31489(kasB)

MCX:	BN42_40170(kasB)

MCZ:	BN45_50578(kasB)

MORY:

MO_002355(kasB)

MLE:	ML1656(kasB)

MLB:	MLBr01656(kasB)

MPA:	MAP_1999(kasB) MAP_3485(kasB)

MAO:	MAP4_0292 MAP4_1826

MAVI:

RC58_09125

MAVU:

RE97_09130

MAV:	MAV_2191 MAV_4343

MAVM:

MAA44156_02223(kasB_1) MAA44156_03789(kasB_2)

MIT:	OCO_21780 OCO_42090

MIA:	OCU_21960 OCU_42010

MID:	MIP_03076 MIP_06344

MYO:	OEM_19670 OEM_42440

MCHI:

AN480_11270 AN480_22070

MIR:	OCQ_20880 OCQ_43360

MMAL:

CKJ54_09720 CKJ54_20115

MLP:	MLM_1920 MLM_3503

MMAN:

MMAN_18030(kasB_1) MMAN_30190(kasB_2)

MSER:

MTY59_05580(kasB) MTY59_37850(kasB)

MSA:	Mycsm_00734 Mycsm_03981

MUL:	MUL_1303(kasB)

MMI:	MMAR_3339(kasB)

MMAE:

MMARE11_32400(kasB)

MLI:	MULP_03600(kasB)

MPSE:

MPSD_34160(kasB)

MSHO:

MSHO_47510(kasB)

MMC:	Mmcs_0783 Mmcs_3367

MKM:	Mkms_0798 Mkms_3429

MJL:	Mjls_0779 Mjls_3378

MMM:	W7S_10240 W7S_21055

MKN:	MKAN_03350

MYV:	G155_18580 G155_24920

MYE:	AB431_04975 AB431_19265

MHAD:

B586_09890

MDX:	BTO20_06565 BTO20_13085

MSHG:

MSG_01053(kasB_1) MSG_03171(kasB_2)

MFJ:	MFLOJ_00450(kasB_1) MFLOJ_23320(kasB_2)

MSTO:

MSTO_01110(kasB_1) MSTO_27280(kasB_2)

MSIM:

MSIM_14500(kasB_1) MSIM_45150(kasB_2)

MSAK:

MSAS_12210(kasB_1) MSAS_12510(kasB_2)

MKU:	I2456_16060 I2456_16415

MLW:	MJO58_05580(kasB) MJO58_16835(kasB)

MXE:	MYXE_20720(kasB) MYXE_43070

MNV:	MNVI_22730 MNVI_45160(kasB)

MPAG:

C0J29_07930 C0J29_18645

MNM:	MNVM_02380(kasB) MNVM_40280

MGOR:

H0P51_17365 H0P51_25650

MCOO:

MCOO_12830(kasB_1) MCOO_39080(kasB_2)

MBAI:

MB901379_03011(kasB)

MSEO:

MSEO_14160(kasB_1) MSEO_19580(kasB_2)

MHEK:

JMUB5695_02081(kasB) JMUB5695_04192

MGAU:

MGALJ_21320 MGALJ_52620

MLJ:	MLAC_22600(kasB)

MBRD:

MBRA_10910 MBRA_35610(kasB)

MSHJ:

MSHI_10160(kasB)

MMAM:

K3U93_14880

MSPG:

F6B93_13970

MOT:	LTS72_07815

MLM:	MLPF_0931(kasB)

MPAA:

MKK62_10055(kasB) MKK62_21435

MMEH:

M5I08_06355 M5I08_12040(kasB)

MKY:	IWGMT90018_24120 IWGMT90018_57110

MADI:

A7U43_13130

MWU:	PT015_07480(kasB) PT015_20985

MYW:	BVC93_22720

MYJ:	BCA37_20100

MHAF:

ACEL92_10985(kasB) ACEL92_13695(kasB)

MSM:	MSMEG_1204 MSMEG_4328

MSG:	MSMEI_1170(kasB) MSMEI_4228(kasB)

MSB:	LJ00_05995 LJ00_21450

MSN:	LI99_05995 LI99_21455

MSH:	LI98_05995 LI98_21460

MVA:

Mvan_3757

MGI:

Mflv_2776

MSP:	Mspyr1_22160

MCB:	Mycch_3279

MNE:	D174_18310

MYN:	MyAD_17955

MFT:	XA26_37940 XA26_50520

MPHL:

MPHLCCUG_01036(kasB_1) MPHLCCUG_03393(kasB_2)

MVQ:

MYVA_3579

MLL:	B1R94_04715 B1R94_10585

MRH:	MycrhN_0961 MycrhN_4434

MTHN:

4412656_01785(kasB)

MHAS:

MHAS_00020(kasB_1) MHAS_01448(kasB_2)

MDU:	MDUV_08130

MCHT:

MCHIJ_33630

MDR:	MDOR_04350 MDOR_24820

MAUU:

NCTC10437_03514(kasB_1)

MMAG:

MMAD_09900(kasB_1) MMAD_35140 MMAD_50950

MMOR:

MMOR_29430 MMOR_56170

MFX:	MFAL_13640

MAIC:

MAIC_34220 MAIC_46930

MIJ:	MINS_32350

MALV:

MALV_02270

MTY:	MTOK_56280

MPSC:

MPSYJ_30180

MARZ:

MARA_61340

MGAD:

MGAD_02940 MGAD_51510

MHEV:

MHEL_60260

MSAR:

MSAR_35160

MANY:

MANY_19080 MANY_48670

MAUB:

MPOF:

MPHU:

MMUC:

MMAT:

MMAGJ_40560 MMAGJ_73570

MBOK:

MBOE_35990

MFG:	K6L26_13125 K6L26_26205

MSEI:

MSEDJ_47250

MFLV:

NCTC10271_01898(kasB_2) NCTC10271_04318(kasB_3)

MCEE:

MCEL_03180 MCEL_25410

MBRM:

L2Z93_001322

MMON:

EWR22_04110 EWR22_17425

MGO:	AFA91_18465 AFA91_32665

MHOL:

K3U96_10645 K3U96_22490

MSEN:

K3U95_05495 K3U95_16000

MPAE:

K0O64_04540 K0O64_18630

MRF:	MJO55_16905(kasB)

MDF:	K0O62_18265

MCRO:

MI149_05220 MI149_19455(kasB)

MGRO:

FZ046_22650

MAUS:

JN090_19085 JN090_24550

MFRE:

EXE63_26455

MBUG:

MU0053_001992(kasB)

MYQ:	TUM20985_10790 TUM20985_20830 TUM20985_48590(kasB)

MFLU:

HZU40_24650

MYH:	QU592_05775 QU592_19275(kasB)

MPAT:

MPNTM1_02316 MPNTM1_03379

MKR:	MKOR_04700(kasB)

MPAK:

MIU77_06595(kasB)

MJD:	JDM601_1649(kasB) JDM601_2027(kasB)

MTER:

4434518_01562(kasB_1) 4434518_01976(kasB_2)

MMIN:

MMIN_32490(kasB)

MHIB:

MHIB_10830(kasB) MHIB_26020

MHER:

K3U94_09075 K3U94_17975

MVM:	MJO54_09165(kasB) MJO54_18130(kasB)

MKK:	MU0083_001481(kasB)

» show all

Reference

PMID:11600501

Authors

Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, Lonsdale JT

Title

Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.

Journal

J Biol Chem 276:47029-37 (2001)
DOI:10.1074/jbc.M108903200

Sequence

[mtu:Rv2246]

Reference

PMID:24809459

Authors

Vilcheze C, Molle V, Carrere-Kremer S, Leiba J, Mourey L, Shenai S, Baronian G, Tufariello J, Hartman T, Veyron-Churlet R, Trivelli X, Tiwari S, Weinrick B, Alland D, Guerardel Y, Jacobs WR Jr, Kremer L

Title

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis.

Journal

PLoS Pathog 10:e1004115 (2014)
DOI:10.1371/journal.ppat.1004115

Sequence

[mtu:Rv2246]

Reference

PMID:12464486

Authors

Slayden RA, Barry CE 3rd

Title

The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis.

Journal

Tuberculosis (Edinb) 82:149-60 (2002)
DOI:10.1054/tube.2002.0333

LinkDB

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