KEGG ORTHOLOGY: K27071

ORTHOLOGY: K27071

Entry

K27071                      KO

Symbol

hadA

Name

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Reaction

R13260

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13264

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13268

ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27071  hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K27071  hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K27071  hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA

Genes

MTU:	Rv0635(hadA)

MTV:

RVBD_0635

MTC:

MT0664

MRA:

MRA_0646

MTF:	TBFG_10648

MTB:	TBMG_00646

MTK:	TBSG_00650

MTZ:	TBXG_000639

MTG:	MRGA327_03985

MTI:	MRGA423_03965

MTE:	CCDC5079_0592

MTUR:

CFBS_0667

MTL:	CCDC5180_0585

MTO:	MTCTRI2_0650

MTD:

UDA_0635

MTN:	ERDMAN_0703

MTJ:	J112_03405

MTUB:

MT7199_0653(hadA)

MTUC:

J113_04545

MTUE:

J114_03400

MTX:	M943_03315

MTUH:

MTUL:

MTUT:

MTUU:

MTQ:	HKBS1_0667

MBO:	BQ2027_MB0654(hadA)

MBB:

BCG_0684

MBT:

JTY_0654

MBM:	BCGMEX_0655

MBK:	K60_006770

MBX:

BCGT_0424

MAF:

MAF_06440

MMIC:

RN08_0710

MCE:	MCAN_06341

MCQ:	BN44_10697

MCV:	BN43_20059

MCX:	BN42_20379

MCZ:	BN45_10729

MORY:

MO_000675(hadA)

MLE:

MLB:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MAVM:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MSER:

MSA:	Mycsm_00908

MUL:

MUL_0720

MMI:

MMAR_0968

MMAE:

MMARE11_09170

MLI:	MULP_01087

MPSE:

MSHO:

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_19335

MYV:	G155_06825

MYE:	AB431_05130

MHAD:

B586_19030

MDX:	BTO20_07095

MSHG:

MSG_00830

MFJ:	MFLOJ_26320

MSTO:

MSTO_30130

MSIM:

MSIM_16550

MSAK:

MSAS_44070

MKU:	I2456_04915(hadA)

MLW:	MJO58_04425(hadA)

MXE:	MYXE_40460

MNV:	MNVI_24720

MPAG:

C0J29_05300

MNM:	MNVM_11730

MGOR:

H0P51_04825(hadA)

MCOO:

MBAI:

MSEO:

MHEK:

MGAU:

MLJ:	MLAC_35430

MBRD:

MBRA_07000

MSHJ:

MSHI_28060

MMAM:

K3U93_04020(hadA)

MSPG:

F6B93_03995(hadA)

MOT:	LTS72_20820(hadA)

MLM:

MLPF_2422

MPAA:

MKK62_20395(hadA)

MMEH:

M5I08_03270(hadA)

MKY:	IWGMT90018_09640

MADI:

A7U43_25730

MWU:	PT015_22070(hadA)

MYW:	BVC93_04805

MYJ:	BCA37_07205

MSM:	MSMEG_1340

MSG:	MSMEI_1302

MSB:	LJ00_06680

MSN:	LI99_06680

MSH:	LI98_06680

MVA:

Mvan_1230

MGI:

Mflv_5121

MSP:	Mspyr1_45390

MCB:	Mycch_0876

MNE:	D174_06255

MYN:	MyAD_06130

MFT:	XA26_13630

MPHL:

MPHLCCUG_01193

MVQ:

MYVA_1039

MLL:	B1R94_04860

MRH:	MycrhN_0783

MTHN:

4412656_00849

MHAS:

MHAS_00156

MDU:	MDUV_34760

MCHT:

MCHIJ_01660

MDR:	MDOR_05160

MAUU:

NCTC10437_01012

MMAG:

MMAD_10290

MMOR:

MMOR_54940

MFX:	MFAL_21750

MAIC:

MAIC_46650

MIJ:	MINS_12790

MALV:

MALV_24920

MTY:	MTOK_31150

MPSC:

MARZ:

MGAD:

MANY:

MAUB:

MPOF:

MPHU:

MMUC:

C1S78_023360(hadA)

MMAT:

MMAGJ_41920

MBOK:

MBOE_62980

MFG:	K6L26_25820(hadA)

MSEI:

MSEDJ_23050

MFLV:

NCTC10271_04189

MCEE:

MCEL_23830

MMON:

EWR22_04960(hadA)

MGO:	AFA91_32190

MHOL:

K3U96_21975(hadA)

MSEN:

K3U95_05910(hadA)

MPAE:

K0O64_04710(hadA)

MRF:	MJO55_04985(hadA)

MDF:	K0O62_05315(hadA)

MCRO:

MI149_05365(hadA)

MGRO:

FZ046_10985(hadA)

MAUS:

JN090_04890(hadA)

MFRE:

EXE63_09910(hadA)

MBUG:

MU0053_003879(hadA)

MKR:	MKOR_23130

MPAK:

MIU77_15290(hadA)

MAB:

MAB_3898c

MMV:	MYCMA_2161

MABB:

MASS_3911

MABL:

MMASJCM_3915

MCHE:

BB28_19990

MIZ:	BAB75_22235

MSTE:

MSTE_04050

MSAO:

MYCSP_18045

MSAL:

DSM43276_03694

MJD:	JDM601_0658

MTER:

MMIN:

MHIB:

MHER:

MVM:	MJO54_03680(hadA)

MKK:	MU0083_000611(hadA)

ASD:

AS9A_0395

RHA:	RHA1_ro01984

RER:	RER_17130(hadA)

REY:

O5Y_08200

REB:	XU06_08440

RQI:	C1M55_08670

ROP:	ROP_16610(hadA)

ROA:	Pd630_LPD06155

RPY:	Y013_09115

RBY:	CEJ39_20005

RHB:

NY08_4830

RAV:	AAT18_18995

RHW:	BFN03_12350

RRZ:	CS378_08455

RHU:	A3Q40_00320

RHQ:	IM25_00955

RHOD:

AOT96_19040

RRT:	4535765_03637

RCR:	NCTC10994_03621

RTM:	G4H71_15970

RKO:	JWS14_10145

RGO:	KYT97_10025

ROZ:	CBI38_08150

RPSK:

JWS13_35690

RGOR:

NMQ04_15865(hadA)

RHOP:

D8W71_24865

RHOO:

RA302_08585(hadA)

RHOU:

KZJ41_20105

RHOW:

A4U64_05715

RHOJ:

JVH1_27365(hadA)

RHOS:

QWW67_08760(hadA)

RHOQ:

QWW98_08765(hadA)

RHOY:

QNA09_16610(hadA)

RHOH:

CPI83_20610

RHOX:

RBB84_13835(hadA)

RHJS:

OYT95_28780(hadA)

RFA:	A3L23_02895

RHS:	A3Q41_00466

REQ:

REQ_36890

PDEF:

P9209_09845(hadA) P9209_22520(hadA)

PSOW:

ABI214_04905(hadA) ABI214_19500(hadA)

TOY:	FO059_03315

» show all

Reference

PMID:17804795

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

Sequence

[mtu:Rv0635]

LinkDB

DBGET integrated database retrieval system