KEGG   REACTION: R13264
Entry
R13264                      Reaction                               
Name
very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)
Definition
Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Very-long-chain trans-2-enoyl-[acyl-carrier protein] + H2O
Equation
C22863 <=> C22864 + C00001
Comment
general reaction
Reaction class
RC01095  C22863_C22864
Enzyme
4.2.1.-
Pathway
rn00074  Mycolic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
M00886  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R13264  Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Very-long-chain trans-2-enoyl-[acyl-carrier protein] + H2O
Orthology
K27071  meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]
K27072  meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]
K27689  meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]
Reference
1  [PMID:17804795]
  Authors
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A
  Title
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104
Reference
2  [PMID:15653820]
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005
Reference
3  [PMID:22216317]
  Authors
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.
  Title
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define  the specificity of the mycolic acid elongation complexes.
  Journal
PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564
LinkDB

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