KEGG ORTHOLOGY: K27072

ORTHOLOGY: K27072

Entry

K27072                      KO

Symbol

hadB

Name

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Reaction

R13260

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13264

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13268

ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

R13272

ultra-long-chain-di-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27072  hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K27072  hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K27072  hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB

Other DBs

COG:

COG2030

Genes

MTU:	Rv0636(hadB)

MTV:

RVBD_0636

MTC:

MT0665

MRA:

MRA_0647

MTF:	TBFG_10649

MTB:	TBMG_00647

MTK:	TBSG_00651

MTZ:	TBXG_000640

MTI:	MRGA423_03970

MTE:	CCDC5079_0593

MTUR:

CFBS_0668(hadB)

MTL:	CCDC5180_0586

MTO:	MTCTRI2_0651

MTD:

UDA_0636

MTN:	ERDMAN_0704

MTJ:	J112_03410

MTUB:

MT7199_0654(hadB)

MTUC:

J113_04550

MTUE:

J114_03405

MTX:	M943_03320

MTUH:

I917_04550

MTUL:

TBHG_00632

MTUT:

HKBT1_0668(hadB)

MTUU:

HKBT2_0669(hadB)

MTQ:	HKBS1_0668(hadB)

MBO:	BQ2027_MB0655(hadB)

MBB:

BCG_0685

MBT:

JTY_0655

MBM:	BCGMEX_0656

MBK:	K60_006780

MBX:

BCGT_0425

MAF:

MAF_06450

MMIC:

RN08_0711

MCE:	MCAN_06351

MCQ:	BN44_10698

MCV:	BN43_20060

MCX:	BN42_20380

MCZ:	BN45_10730

MORY:

MO_000676(hadB)

MLE:

MLB:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MAVM:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MMAN_32400(hadB)

MSER:

MTY59_07550(hadB)

MSA:	Mycsm_00909

MUL:

MUL_0721

MMI:

MMAR_0969

MMAE:

MMARE11_09180

MLI:	MULP_01088

MPSE:

MPSD_11010(hadB)

MSHO:

MSHO_27480(hadB)

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_19340

MYV:	G155_06830

MYE:	AB431_05135

MHAD:

B586_19025

MDX:	BTO20_07100

MSHG:

MSG_00831(hadB)

MFJ:	MFLOJ_26310(hadB)

MSTO:

MSTO_30120(hadB)

MSIM:

MSIM_16540(hadB)

MSAK:

MSAS_44080(hadB)

MKU:	I2456_04920(hadB)

MLW:	MJO58_04430(hadB)

MXE:	MYXE_40450(hadB)

MNV:	MNVI_24730(hadB)

MPAG:

C0J29_05305

MNM:	MNVM_11720(hadB)

MGOR:

H0P51_04830(hadB)

MCOO:

MCOO_41270(hadB)

MBAI:

MB901379_00828

MSEO:

MSEO_47800(hadB)

MHEK:

JMUB5695_03950(hadB)

MGAU:

MGALJ_53980(hadB)

MLJ:	MLAC_35420(hadB)

MBRD:

MBRA_06990(hadB)

MSHJ:

MSHI_28050(hadB)

MMAM:

K3U93_04025(hadB)

MSPG:

F6B93_04000(hadB)

MOT:	LTS72_20815(hadB)

MLM:

MLPF_2421

MPAA:

MKK62_20390(hadB)

MMEH:

M5I08_03275(hadB)

MKY:	IWGMT90018_09650(hadB)

MADI:

A7U43_25725

MWU:	PT015_22075(hadB)

MYW:	BVC93_04800

MYJ:	BCA37_07210

MSM:	MSMEG_1341

MSG:	MSMEI_1303

MSB:	LJ00_06685

MSN:	LI99_06685

MSH:	LI98_06685

MVA:

Mvan_1231

MGI:

Mflv_5120

MSP:	Mspyr1_45380

MCB:	Mycch_0877

MNE:	D174_06260

MYN:	MyAD_06135

MFT:	XA26_13640

MPHL:

MPHLCCUG_01194

MVQ:

MYVA_1040

MLL:	B1R94_04865

MRH:	MycrhN_0782

MTHN:

4412656_00850

MHAS:

MHAS_00157(phaJ_1)

MDU:	MDUV_34750(hadB)

MCHT:

MCHIJ_01650(hadB)

MDR:	MDOR_05170(hadB)

MAUU:

NCTC10437_01013

MMAG:

MMAD_10300(hadB)

MMOR:

MMOR_54930(hadB)

MFX:	MFAL_21740(hadB)

MAIC:

MAIC_46640

MIJ:	MINS_12800

MALV:

MALV_24910

MTY:	MTOK_31160(hadB)

MPSC:

MPSYJ_54460

MARZ:

MARA_28760

MGAD:

MGAD_28920(hadB)

MHEV:

MHEL_12740(hadB)

MSAR:

MSAR_24520

MANY:

MANY_48870

MAUB:

MAUB_22720(hadB)

MPOF:

MPOR_15070(hadB)

MPHU:

MPHO_47770(hadB)

MMUC:

C1S78_023355(hadB)

MMAT:

MMAGJ_41930

MBOK:

MBOE_62970

MFG:	K6L26_25815(hadB)

MSEI:

MSEDJ_23060

MFLV:

NCTC10271_04188

MCEE:

MCEL_23820(hadB)

MBRM:

L2Z93_003295(hadB)

MMON:

EWR22_04965(hadB)

MGO:	AFA91_32185

MHOL:

K3U96_21970(hadB)

MSEN:

K3U95_05915(hadB)

MPAE:

K0O64_04715(hadB)

MRF:	MJO55_04990(hadB)

MDF:	K0O62_05320(hadB)

MCRO:

MI149_05370(hadB)

MGRO:

FZ046_10990(hadB)

MAUS:

JN090_04895(hadB)

MFRE:

EXE63_09905(hadB)

MBUG:

MU0053_003878(hadB)

MKR:	MKOR_23120(hadB)

MPAK:

MIU77_15285(hadB)

MAB:

MAB_3897c

MMV:	MYCMA_05235

MABB:

MASS_3910

MABL:

MMASJCM_3914

MCHE:

BB28_19985

MIZ:	BAB75_22230

MSTE:

MSTE_04049

MSAO:

MYCSP_18040

MSAL:

DSM43276_03693

MJD:	JDM601_0659

MTER:

4434518_00645

MMIN:

MMIN_23280(hadB)

MHIB:

MHIB_01740(hadB)

MHER:

K3U94_03705(hadB)

MVM:	MJO54_03685(hadB)

MKK:	MU0083_000612(hadB)

ASD:	AS9A_0396(hadB)

RHA:	RHA1_ro01983

RER:	RER_17140(hadB)

REY:

O5Y_08205

REB:	XU06_08445

RQI:	C1M55_08675

ROP:	ROP_16600(hadB)

ROA:	Pd630_LPD06154

RPY:	Y013_09110

RBY:	CEJ39_20000

RHB:

NY08_4831

RAV:	AAT18_18990

RHW:	BFN03_12345

RRZ:	CS378_08450

RHU:	A3Q40_00321

RHQ:	IM25_00950

RHOD:

AOT96_19045

RRT:	4535765_03636

RCR:	NCTC10994_03622

RTM:	G4H71_15975(hadB)

RKO:	JWS14_10140(hadB)

RGO:	KYT97_10020(hadB)

ROZ:	CBI38_08155

RPSK:

JWS13_35695(hadB)

RGOR:

NMQ04_15860(hadB)

RHOP:

D8W71_24860(hadB)

RHOO:

RA302_08590(hadB)

RHOU:

KZJ41_20100(hadB)

RHOW:

A4U64_05720

RHOJ:

JVH1_27370(hadB)

RHOS:

QWW67_08755(hadB)

RHOQ:

QWW98_08760(hadB)

RHOY:

QNA09_16605(hadB)

RHOH:

CPI83_20605

RHOX:

RBB84_13830(hadB)

RHJS:

OYT95_28785(hadB)

RFA:	A3L23_02896

RHS:	A3Q41_00465

REQ:

REQ_36880

PDEF:

P9209_09850(hadB)

PSOW:

ABI214_19505(hadB)

TPR:

Tpau_0739

TSM:	ASU32_03805

TPUL:

TPB0596_07450(hadB)

TSD:	MTP03_06310(hadB)

TOY:	FO059_03320

» show all

Reference

PMID:17804795

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

Sequence

[mtu:Rv0636]

LinkDB

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