KEGG   ORTHOLOGY: K27503
Entry
K27503            Tight     KO                                     
Symbol
CYP725A22
Name
taxane 9alpha-hydroxylase [EC:1.14.14.185]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R13550  5,20-epoxytaxa-11-en-4alpha-yl acetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (9alpha-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K27503  CYP725A22; taxane 9alpha-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K27503  CYP725A22; taxane 9alpha-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.185  taxane 9alpha-hydroxylase
     K27503  CYP725A22; taxane 9alpha-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP725 family
   K27503  CYP725A22; taxane 9alpha-hydroxylase
Genes
AG: ATG29967(CYP725A22)
Reference
PMID:28878800
  Authors
Liao W, Zhao S, Zhang M, Dong K, Chen Y, Fu C, Yu L
  Title
Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis.
  Journal
Front Plant Sci 8:1468 (2017)
DOI:10.3389/fpls.2017.01468
  Sequence
[ag:ATG29967]
Reference
PMID:37897038
  Authors
Zhang Y, Wiese L, Fang H, Alseekh S, Perez de Souza L, Scossa F, Molloy J, Christmann M, Fernie AR.
  Title
Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis.
  Journal
Mol Plant 16:1951-1961 (2023)
DOI:10.1016/j.molp.2023.10.016
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