KEGG   ORTHOLOGY: K27793
Entry
K27793                      KO                                     
Symbol
DPAS
Name
dihydroprecondylocarpine acetate synthase [EC:1.3.1.128]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R13345  precondylocarpine acetate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K27793  DPAS; dihydroprecondylocarpine acetate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.128  precondylocarpine acetate reductase
     K27793  DPAS; dihydroprecondylocarpine acetate synthase
Genes
AG: ANQ45231(DPAS)
Reference
PMID:29724909
  Authors
Caputi L, Franke J, Farrow SC, Chung K, Payne RME, Nguyen TD, Dang TT, Soares Teto Carqueijeiro I, Koudounas K, Duge de Bernonville T, Ameyaw B, Jones DM, Vieira IJC, Courdavault V, O'Connor SE
  Title
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.
  Journal
Science 360:1235-1239 (2018)
DOI:10.1126/science.aat4100
  Sequence
[ag:ANQ45231]
Reference
PMID:36045295
  Authors
Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrubbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jorgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD.
  Title
A microbial supply chain for production of the anti-cancer drug vinblastine.
  Journal
Nature 609:341-347 (2022)
DOI:10.1038/s41586-022-05157-3
  Sequence
[ag:ANQ45231]
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