KEGG   REACTION: R13345
Entry
R13345                      Reaction                               
Name
precondylocarpine acetate:NADP+ oxidoreductase
Definition
Dihydroprecondylocarpine acetate + NADP+ <=> Precondylocarpine acetate + NADPH + H+
Equation
Reaction class
RC03592  C22934_C22935
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.128
     R13345  Dihydroprecondylocarpine acetate + NADP+ <=> Precondylocarpine acetate + NADPH + H+
Orthology
K27793  dihydroprecondylocarpine acetate synthase [EC:1.3.1.128]
Reference
1  [PMID:36045295]
  Authors
Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrubbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jorgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD.
  Title
A microbial supply chain for production of the anti-cancer drug vinblastine.
  Journal
Nature 609:341-347 (2022)
DOI:10.1038/s41586-022-05157-3
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