KEGG   ORTHOLOGY: K28368
Entry
K28368                      KO                                     
Symbol
TB506
Name
taxol side chain-2'-hydroxylase [EC:1.14.14.193]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R08173  3'-N-debenzoyl-2'-deoxytaxol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K28368  TB506; taxol side chain-2'-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.193  taxol side chain-2'-hydroxylase
     K28368  TB506; taxol side chain-2'-hydroxylase
Genes
CJF: 131049141
AG: AKH04263
Reference
PMID:16137660
  Authors
Long RM, Croteau R.
  Title
Preliminary assessment of the C13-side chain 2'-hydroxylase involved in taxol biosynthesis.
  Journal
Biochem Biophys Res Commun 338:410-7 (2005)
DOI:10.1016/j.bbrc.2005.08.119
Reference
PMID:32528936
  Authors
Sanchez-Munoz R, Perez-Mata E, Almagro L, Cusido RM, Bonfill M, Palazon J, Moyano E.
  Title
A Novel Hydroxylation Step in the Taxane Biosynthetic Pathway: A New Approach to Paclitaxel Production by Synthetic Biology.
  Journal
Front Bioeng Biotechnol 8:410 (2020)
DOI:10.3389/fbioe.2020.00410
  Sequence
[ag:AKH04263]
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