KEGG   MODULE: M00013
Entry
M00013            Pathway   Module                                 
Name
Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
Definition
(K00248,K00232) (K07511,K14729) K05605 K23146 K00140
Diagram
M00013

Orthology
K00248  
ACADS; butyryl-CoA dehydrogenase [EC:1.3.8.1] [RN:R04432]
K00232  
E1.3.3.6; acyl-CoA oxidase [EC:1.3.3.6] [RN:R12356]
K07511  
enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03045]
K14729  
multifunctional beta-oxidation protein [EC:4.2.1.-] [RN:R03045]
K05605  
3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] [RN:R03157 R03158]
K23146  
3-hydroxypropionate dehydrogenase [EC:1.1.1.59] [RN:R01608]
K00140  
malonate-semialdehyde dehydrogenase (acetylating) [EC:1.2.1.18] [RN:R00740]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00410  beta-Alanine metabolism
map00640  Propanoate metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
Reaction
R04432,R12356  
R03045  
R03158  
R01608  
R00705,R00706  
Compound
C00100  Propanoyl-CoA
C00894  Propenoyl-CoA
C05668  3-Hydroxypropionyl-CoA
C01013  3-Hydroxypropanoate
C00222  3-Oxopropanoate
C00024  Acetyl-CoA
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Reference
PMID:24497638
  Authors
Otzen C, Bardl B, Jacobsen ID, Nett M, Brock M
  Title
Candida albicans utilizes a modified beta-oxidation pathway for the degradation of toxic propionyl-CoA.
  Journal
J Biol Chem 289:8151-69 (2014)
DOI:10.1074/jbc.M113.517672
LinkDB

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