KEGG   MODULE: M00123
Entry
M00123            Pathway   Module                                 
Name
Biotin biosynthesis, pimeloyl-ACP/CoA => biotin
Definition
K00652 ((K00833,K19563) K01935,K19562) K01012
Diagram
M00123

Orthology
K00652  
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] [RN:R10124 R03210]
K00833  
bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62] [RN:R03231]
K19563  
bioA; lysine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.105] [RN:R10699]
K19562  
BIO3-BIO1; bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:6.3.3.3 2.6.1.62] [RN:R03231 R03182]
K01935  
bioD; dethiobiotin synthetase [EC:6.3.3.3] [RN:R03182]
K01012  
bioB; biotin synthetase [EC:2.8.1.6] [RN:R01078]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00780  Biotin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R10124  
R03210  
R03231  
R10699  
R03182  
R01078  
Compound
C19845  Pimeloyl-[acyl-carrier protein]
C01092  8-Amino-7-oxononanoate
C01063  Pimeloyl-CoA
C01037  7,8-Diaminononanoate
C01909  Dethiobiotin
C00120  Biotin
Reference
PMID:21437340
  Authors
Lin S, Cronan JE
  Title
Closing in on complete pathways of biotin biosynthesis.
  Journal
Mol Biosyst 7:1811-21 (2011)
DOI:10.1039/c1mb05022b
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