KEGG   MODULE: M00577
Entry
M00577            Pathway   Module                                 
Name
Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
Definition
K01906 K00652 (K00833,K19563) K01935 K01012
Diagram
M00577  Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
M00577

Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00780  Biotin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Orthology
K01906  
bioW; 6-carboxyhexanoate--CoA ligase [EC:6.2.1.14] [RN:R03209]
K00652  
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] [RN:R03210]
K00833  
bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62] [RN:R03231]
K19563  
bioA; lysine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.105] [RN:R10699]
K01935  
bioD; dethiobiotin synthetase [EC:6.3.3.3] [RN:R03182]
K01012  
bioB; biotin synthetase [EC:2.8.1.6] [RN:R01078]
Complete
pca  Syntrophotalea carbinolica
pace  Syntrophotalea acetylenica
pef  Syntrophotalea acetylenivorans
aagg  Anatilimnocola aggregata
tpi  Treponema primitia
tri  Treponema ruminis
aae  Aquifex aeolicus
hya  Hydrogenobaculum sp. Y04AAS1
hho  Hydrogenobaculum sp. HO
hys  Hydrogenobaculum sp. SN
hth  Hydrogenobacter thermophilus
hte  Hydrogenobacter thermophilus
tal  Thermocrinis albus
trd  Thermocrinis ruber
pdiz  Pampinifervens diazotrophicum
pflo  Pampinifervens florentissimum
sul  Sulfurihydrogenibium sp. YO3AOP1
saf  Sulfurihydrogenibium azorense
pmx  Persephonella marina
tam  Thermovibrio ammonificans
dte  Desulfurobacterium thermolithotrophum
tye  Thermodesulfovibrio yellowstonii
tob  Thermodesulfovibrio obliviosus
lfc  Leptospirillum ferrooxidans
lfi  Leptospirillum ferriphilum ML-04
lfp  Leptospirillum ferriphilum YSK
bsu  Bacillus subtilis subsp. subtilis 168
bsr  Bacillus subtilis subsp. subtilis RO-NN-1
bsl  Bacillus subtilis subsp. subtilis BSP1
bsh  Bacillus subtilis subsp. subtilis 6051-HGW
bsy  Bacillus subtilis subsp. subtilis BAB-1
bsut  Bacillus subtilis subsp. subtilis AG1839
bsul  Bacillus subtilis subsp. subtilis JH642
bsus  Bacillus subtilis subsp. subtilis OH 131.1
bso  Bacillus subtilis subsp. natto BEST195
bsn  Bacillus subtilis BSn5
bsq  Bacillus subtilis QB928
bsx  Bacillus subtilis XF-1
bsp  Bacillus subtilis PY79
bss  Bacillus subtilis subsp. spizizenii W23
bst  Bacillus spizizenii TU-B-10
bit  Bacillus spizizenii T30
bli  Bacillus licheniformis ATCC 14580
bld  Bacillus licheniformis DSM 13 = ATCC 14580
blh  Bacillus paralicheniformis
bay  Bacillus velezensis FZB42
bya  Bacillus velezensis YAU B9601-Y2
bqy  Bacillus velezensis YAU B9601-Y2
bamp  Bacillus velezensis AS43.3
baml  Bacillus velezensis UCMB5036
bama  Bacillus velezensis UCMB5033
bamn  Bacillus velezensis UCMB5113
bamb  Bacillus velezensis NAU-B3
bamt  Bacillus velezensis TrigoCor1448
bamy  Bacillus velezensis SQR9
bmp  Bacillus velezensis JS25R
bao  Bacillus amyloliquefaciens DSM 7
baz  Bacillus amyloliquefaciens TA208
bql  Bacillus amyloliquefaciens LL3
bxh  Bacillus amyloliquefaciens XH7
bami  Bacillus amyloliquefaciens IT-45
bamc  Bacillus amyloliquefaciens CC178
bamf  Bacillus amyloliquefaciens LFB112
bsia  Bacillus siamensis
bae  Bacillus atrophaeus
bvm  Bacillus vallismortis
bson  Bacillus sonorensis
bht  Bacillus halotolerans
bmoj  Bacillus mojavensis
biq  Bacillus inaquosorum
bstr  Bacillus stercoris
bgy  Bacillus glycinifermentans
bcab  Bacillus cabrialesii
bry  Bacillus rugosus
bjs  Bacillus sp. JS
bacp  Bacillus sp. Pc3
bacb  Bacillus sp. BH072
baco  Bacillus sp. OxB-1
bacy  Bacillus sp. YP1
bacl  Bacillus sp. BS34A
balm  Bacillus sp. LM 4-2
bacs  Bacillus sp. SDLI1
bacq  Bacillus sp. Y1
bafc  Bacillus sp. FCW2
bkn  Bacillus kandeliae
bazs  Bacillus sp. 275
bach  Bacillus sp. H15-1
bacj  Bacillus sp. 1s-1
bawr  Bacillus sp. WR11
bacn  Bacillus sp. N1-1
beo  Priestia filamentosa
bfx  Priestia flexa
bgi  Alkalicoccobacillus gibsonii
bpf  Alkalihalophilus pseudofirmus
lgy  Lysinibacillus varians
lyq  Lysinibacillus sp. Ag94
vpn  Virgibacillus dokdonensis
apak  Aeribacillus pallidus
pasa  Peribacillus asahii
msem  Metabacillus sediminilitoris
ross  Rossellomorea sp. y25
alkl  Alkalihalobacillus sp. LMS39
dom  Domibacillus sp. DTU_2020_1001157_1_SI_ALB_TIR_016
sau  Staphylococcus aureus subsp. aureus N315 (MRSA/VSSA)
sav  Staphylococcus aureus subsp. aureus Mu50 (MRSA/VISA)
saw  Staphylococcus aureus subsp. aureus Mu3 (MRSA/hetero-VISA)
sah  Staphylococcus aureus subsp. aureus JH1 (MRSA/VSSA)
saj  Staphylococcus aureus subsp. aureus JH9 (MRSA/VISA)
sam  Staphylococcus aureus subsp. aureus MW2 (CA-MRSA)
sas  Staphylococcus aureus subsp. aureus MSSA476 (MSSA)
sar  Staphylococcus aureus subsp. aureus MRSA252 (MRSA)
sac  Staphylococcus aureus subsp. aureus COL (MRSA)
sax  Staphylococcus aureus subsp. aureus USA300_TCH1516 (CA-MRSA)
saa  Staphylococcus aureus subsp. aureus USA300_FPR3757 (CA-MRSA)
sao  Staphylococcus aureus subsp. aureus NCTC8325
sae  Staphylococcus aureus subsp. aureus Newman
sad  Staphylococcus aureus subsp. aureus ED98
suu  Staphylococcus aureus subsp. aureus M013 (CA-MRSA)
suv  Staphylococcus aureus subsp. aureus VC40
sue  Staphylococcus aureus subsp. aureus ED133
suj  Staphylococcus aureus subsp. aureus JKD6159 (CA-MRSA)
suc  Staphylococcus aureus subsp. aureus ECT-R 2 (MSSA)
sut  Staphylococcus aureus subsp. aureus T0131 (MRSA)
suq  Staphylococcus aureus subsp. aureus TCH60
suz  Staphylococcus aureus subsp. aureus 11819-97 (CA-MRSA)
sud  Staphylococcus aureus subsp. aureus 71193 (MSSA)
sux  Staphylococcus aureus subsp. aureus HO 5096 0412 (MRSA)
suw  Staphylococcus aureus subsp. aureus TW20 (MRSA)
sug  Staphylococcus aureus subsp. aureus ST398 (MRSA)
suf  Staphylococcus aureus subsp. aureus LGA251 (MRSA)
saua  Staphylococcus aureus subsp. aureus 55/2053
saue  Staphylococcus aureus subsp. aureus 6850 (MSSA)
saun  Staphylococcus aureus subsp. aureus CN1 (CA-MRSA)
saus  Staphylococcus aureus subsp. aureus SA40 (CA-MRSA)
sauu  Staphylococcus aureus subsp. aureus SA957 (CA-MRSA)
saug  Staphylococcus aureus subsp. aureus SA268 (CA-MRSA)
sauz  Staphylococcus aureus subsp. aureus Z172 (MRSA/VISA)
saut  Staphylococcus aureus subsp. aureus ST228/10388 (MRSA)
sauj  Staphylococcus aureus subsp. aureus ST228/10497 (MRSA)
sauk  Staphylococcus aureus subsp. aureus ST228/15532 (MRSA)
sauq  Staphylococcus aureus subsp. aureus ST228/16035 (MRSA)
sauv  Staphylococcus aureus subsp. aureus ST228/18412 (MRSA)
sauw  Staphylococcus aureus subsp. aureus ST228/16125 (MRSA)
saux  Staphylococcus aureus subsp. aureus ST228/18341 (MRSA)
sauy  Staphylococcus aureus subsp. aureus ST228/18583 (MRSA)
sauf  Staphylococcus aureus subsp. aureus FDAARGOS_5
sab  Staphylococcus aureus RF122
suy  Staphylococcus aureus 04-02981 (MRSA)
saub  Staphylococcus aureus 08BA02176 (LA-MRSA)
saum  Staphylococcus aureus M1 (MRSA)
sauc  Staphylococcus aureus CA-347 (MRSA)
saur  Staphylococcus aureus Bmb9393 (MRSA)
saui  Staphylococcus aureus USA300-ISMMS1 (MRSA)
saud  Staphylococcus aureus 502A
sams  Staphylococcus aureus MS4
suh  Staphylococcus argenteus
ser  Staphylococcus epidermidis RP62A (MRSE)
sep  Staphylococcus epidermidis ATCC 12228
sepp  Staphylococcus epidermidis PM221
seps  Staphylococcus epidermidis SEI
ssd  Staphylococcus pseudintermedius HKU10-03
sdt  Staphylococcus pseudintermedius ED99
sdp  Staphylococcus delphini
shu  Staphylococcus hyicus
ssch  Staphylococcus schleiferi 1360-13
sscz  Staphylococcus schleiferi 2317-03
sagq  Staphylococcus agnetis
spet  Staphylococcus pettenkoferi
slz  Staphylococcus lutrae
sfq  Staphylococcus felis
schr  Staphylococcus chromogenes
ssh  Staphylococcus schweitzeri
srai  Staphylococcus ratti
scaq  Staphylococcus casei
ssuc  Staphylococcus succinus
sff  Mammaliicoccus fleurettii
anx  Aneurinibacillus sp. XH2
asoc  Aneurinibacillus soli
athe  Aneurinibacillus thermoaerophilus
aud  Aneurinibacillus uraniidurans
aneu  Aneurinibacillus sp. Ricciae_BoGa-3
tum  Tumebacillus avium
spae  Sporosarcina pasteurii
surl  Sporosarcina ureilytica
fpen  Floricoccus penangensis
cace  Clostridium aceticum
cfm  Clostridium formicaceticum
dor  Desulfosporosinus orientis
dku  Desulfofundulus kuznetsovii
tfr  Thermanaerosceptrum fracticalcis
cthm  Carboxydocella thermautotrophica
rto  Ruminococcus torques
psor  Paraclostridium sordellii
rhom  Romboutsia hominis
tmy  Terrisporobacter mayombei
tki  Thermoanaerobacter kivui
hals  Halocella sp. SP3-1
ifn  Iocasia fonsfrigidae
phar  Peptoniphilus harei
pgk  Peptoniphilus genitalis
cad  Gottschalkia acidurici
vpr  Veillonella parvula
vat  Veillonella atypica
vrm  Veillonella rodentium
vdn  Veillonella dispar
vnk  Veillonella nakazawae
vrg  Veillonella rogosae
vor  Veillonella orientalis
ssg  Selenomonas sputigena
sri  Selenomonas ruminantium subsp. lactilytica
mhg  Megamonas hypermegale
mfun  Megamonas funiformis
pft  Pelosinus fermentans
sted  Sporomusa termitida
scao  Sporomusa carbonis
cdi  Corynebacterium diphtheriae NCTC 13129
cdp  Corynebacterium diphtheriae 241
cdh  Corynebacterium diphtheriae INCA 402
cdt  Corynebacterium diphtheriae HC01
cde  Corynebacterium diphtheriae HC02
cdr  Corynebacterium diphtheriae HC03
cda  Corynebacterium diphtheriae HC04
cdz  Corynebacterium diphtheriae 31A
cdb  Corynebacterium diphtheriae BH8
cds  Corynebacterium diphtheriae C7 (beta)
cdd  Corynebacterium diphtheriae CDCE 8392
cdw  Corynebacterium diphtheriae PW8
cdv  Corynebacterium diphtheriae VA01
cdip  Corynebacterium diphtheriae NCTC11397
ckp  Corynebacterium kroppenstedtii
cpu  Corynebacterium pseudotuberculosis FRC41
cpl  Corynebacterium pseudotuberculosis 3/99-5
cpg  Corynebacterium pseudotuberculosis 316
cpp  Corynebacterium pseudotuberculosis P54B96
cpk  Corynebacterium pseudotuberculosis 1002
cpq  Corynebacterium pseudotuberculosis C231
cpx  Corynebacterium pseudotuberculosis I19
cpz  Corynebacterium pseudotuberculosis PAT10
cor  Corynebacterium pseudotuberculosis 267
cop  Corynebacterium pseudotuberculosis 31
cod  Corynebacterium pseudotuberculosis 1/06-A
cos  Corynebacterium pseudotuberculosis 42/02-A
coi  Corynebacterium pseudotuberculosis CIP 52.97
coe  Corynebacterium pseudotuberculosis 258
cou  Corynebacterium pseudotuberculosis Cp162
cpse  Corynebacterium pseudotuberculosis 48252
cpsu  Corynebacterium pseudotuberculosis CS_10
cpsf  Corynebacterium pseudotuberculosis Ft_2193/67
cul  Corynebacterium ulcerans BR-AD22
cuc  Corynebacterium ulcerans 809
cue  Corynebacterium ulcerans 0102
cun  Corynebacterium ulcerans 210932
cuq  Corynebacterium ulcerans 210931
cuz  Corynebacterium ulcerans 05146
cuj  Corynebacterium ulcerans 131002
cus  Corynebacterium ramonii FRC0011
cvt  Corynebacterium vitaeruminis
coa  Corynebacterium sp. ATCC 6931
cei  Corynebacterium epidermidicanis
clw  Corynebacterium lactis
csp  Corynebacterium simulans
cpho  Corynebacterium phocae
cstr  Corynebacterium striatum
cmin  Corynebacterium minutissimum
cpeg  Corynebacterium pelargi
cgk  Corynebacterium geronticis
crf  Corynebacterium rouxii
cpso  Corynebacterium pseudopelargi
ckf  Corynebacterium kefirresidentii
cprp  Corynebacterium propinquum
camc  Corynebacterium amycolatum
cglu  Corynebacterium glucuronolyticum
csil  Corynebacterium silvaticum
ckw  Corynebacterium kalinowskii
cory  Corynebacterium sp. sy039
cmf  Corynebacterium macginleyi
cacc  Corynebacterium accolens
chin  Corynebacterium hindlerae
cpsp  Corynebacterium pseudodiphtheriticum
cmas  Corynebacterium massiliense
cihu  Corynebacterium ihumii
chad  Corynebacterium hadale
cfou  Corynebacterium fournieri
cfeu  Corynebacterium felinum
cafe  Corynebacterium afermentans subsp. lipophilum
cgoi  Corynebacterium gottingense
cik  Corynebacterium incognita
crhn  Corynebacterium rhinophilum
pac  Cutibacterium acnes KPA171202
pak  Cutibacterium acnes SK137
pav  Cutibacterium acnes TypeIA2 P.acn17
pax  Cutibacterium acnes TypeIA2 P.acn31
paz  Cutibacterium acnes TypeIA2 P.acn33
paw  Cutibacterium acnes 266
pad  Cutibacterium acnes subsp. defendens ATCC 11828
pcn  Cutibacterium acnes 6609
pacc  Cutibacterium acnes C1
pach  Cutibacterium acnes HL096PA1
pacn  Cutibacterium acnes hdn-1
cacn  Cutibacterium acnes KCOM 1861 (= ChDC B594)
pra  Cutibacterium avidum
prl  Cutibacterium modestum
cgrn  Cutibacterium granulosum
mja  Methanocaldococcus jannaschii
mvu  Methanocaldococcus vulcanius
mfs  Methanocaldococcus sp. FS406-22
mif  Methanocaldococcus infernus
mjh  Methanocaldococcus bathoardescens
mesg  Methanocaldococcus lauensis SG7
mesa  Methanocaldococcus lauensis SG1
mig  Methanotorris igneus
mmp  Methanococcus maripaludis S2
mmq  Methanococcus maripaludis C5
mmx  Methanococcus maripaludis C6
mmz  Methanococcus maripaludis C7
mmd  Methanococcus maripaludis X1
mmak  Methanococcus maripaludis KA1
mmao  Methanococcus maripaludis OS7
mmad  Methanococcus maripaludis DSM 2067
mae  Methanococcus aeolicus
mvn  Methanococcus vannielii
mvo  Methanococcus voltae
mok  Methanothermococcus okinawensis
metf  Methanofervidicoccus sp. A16
mru  Methanobrevibacter ruminantium
mol  Methanobrevibacter olleyae
 » show all
Reaction
R03209  
R03210  
R03231  
R10699  
R03182  
R01078  
Compound
C02656  Pimelate
C01063  Pimeloyl-CoA
C01092  8-Amino-7-oxononanoate
C01037  7,8-Diaminononanoate
C01909  Dethiobiotin
C00120  Biotin
Reference
PMID:21437340
  Authors
Lin S, Cronan JE
  Title
Closing in on complete pathways of biotin biosynthesis.
  Journal
Mol Biosyst 7:1811-21 (2011)
DOI:10.1039/c1mb05022b
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