KEGG   MODULE: M00643
Entry
M00643            Signature Module                                 
Name
Multidrug resistance, efflux pump MexXY-OprM
Definition
K18129 K18094+K18095+K18139
Diagram
M00643

Orthology
K18129  
mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
K18094  
mexX; membrane fusion protein
K18095  
mexY; multidrug efflux pump
K18139  
oprM; outer membrane protein
Class
Signature modules; Gene set; Drug resistance
Reference
  Authors
Llanes C, Hocquet D, Vogne C, Benali-Baitich D, Neuwirth C, Plesiat P
  Title
Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.
  Journal
Antimicrob Agents Chemother 48:1797-802 (2004)
DOI:10.1128/AAC.48.5.1797-1802.2004
Reference
  Authors
Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T
  Title
Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 44:2242-6 (2000)
DOI:10.1128/AAC.44.9.2242-2246.2000
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
  Authors
Yamamoto M, Ueda A, Kudo M, Matsuo Y, Fukushima J, Nakae T, Kaneko T, Ishigatsubo Y
  Title
Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa.
  Journal
Microbiology 155:3312-21 (2009)
DOI:10.1099/mic.0.028993-0
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