KEGG   MODULE: M00643
Entry
M00643            Signature Module                                 
Name
Multidrug resistance, efflux pump MexXY-OprM
Definition
K18129 K18094+K18095+K18139
Diagram
M00643  Multidrug resistance, efflux pump MexXY-OprM
M00643

Class
Signature modules; Gene set; Drug resistance
Orthology
K18129  
mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
K18094  
mexX; membrane fusion protein
K18095  
mexY; multidrug efflux pump
K18139  
oprM; outer membrane protein
Complete
pae  Pseudomonas aeruginosa PAO1
paev  Pseudomonas aeruginosa PAO1-VE13
paei  Pseudomonas aeruginosa PAO1-VE2
pau  Pseudomonas aeruginosa UCBPP-PA14
paf  Pseudomonas aeruginosa M18
pnc  Pseudomonas aeruginosa NCGM2.S1
paeb  Pseudomonas aeruginosa NCGM 1900
pdk  Pseudomonas aeruginosa DK2
psg  Pseudomonas aeruginosa B136-33
paep  Pseudomonas aeruginosa PA1
paem  Pseudomonas aeruginosa MTB-1
paes  Pseudomonas aeruginosa SCV20265
paeu  Pseudomonas aeruginosa PA38182
paeg  Pseudomonas aeruginosa YL84
paec  Pseudomonas aeruginosa c7447m
paeo  Pseudomonas aeruginosa PAO581
sech  Pseudomonas aeruginosa B18
ppaa  Pseudomonas paraeruginosa
bmv  Burkholderia mallei SAVP1
bml  Burkholderia mallei NCTC 10229
bmn  Burkholderia mallei NCTC 10247
bmaz  Burkholderia mallei NCTC 10247
bmal  Burkholderia mallei 23344
bmae  Burkholderia mallei 6
bmaq  Burkholderia mallei BMQ
bmai  Burkholderia mallei 2000031063
bmab  Burkholderia mallei 2002734299
bps  Burkholderia pseudomallei K96243
bpm  Burkholderia pseudomallei 1710b
bpl  Burkholderia pseudomallei 1106a
bpd  Burkholderia pseudomallei 668
bpr  Burkholderia pseudomallei MSHR346
bpse  Burkholderia pseudomallei MSHR305
bpsm  Burkholderia pseudomallei MSHR511
bpsu  Burkholderia pseudomallei MSHR146
bpsd  Burkholderia pseudomallei MSHR520
bpz  Burkholderia pseudomallei 1026b
bpq  Burkholderia pseudomallei BPC006
bpk  Burkholderia pseudomallei NCTC 13179
bpsh  Burkholderia pseudomallei HBPUB10134a
bpsa  Burkholderia pseudomallei NAU35A-3
bpso  Burkholderia pseudomallei A79A
but  Burkholderia pseudomallei TSV202
bte  Burkholderia thailandensis E264
btj  Burkholderia thailandensis E444
btz  Burkholderia thailandensis H0587
btd  Burkholderia thailandensis MSMB121
btv  Burkholderia thailandensis MSMB59
bthe  Burkholderia thailandensis E254
bthm  Burkholderia thailandensis USAMRU Malaysia #20
btha  Burkholderia thailandensis 2003015869
bthl  Burkholderia thailandensis 2002721643
bok  Burkholderia oklahomensis EO147
boc  Burkholderia oklahomensis C6786
buu  Burkholderia mayonis
bsav  Burkholderia savannae
bhg  Burkholderia humptydooensis FDAARGOS_899
bud  Burkholderia humptydooensis MSMB43
bul  Burkholderia humptydooensis 2002721687
bvi  Burkholderia vietnamiensis G4
bve  Burkholderia vietnamiensis LMG 10929
bur  Burkholderia lata
bcm  Burkholderia orbicola
bch  Burkholderia cenocepacia HI2424
bcen  Burkholderia cenocepacia DDS 22E-1
bcew  Burkholderia cenocepacia DWS 37E-2
bceo  Burkholderia cenocepacia H111
bam  Burkholderia ambifaria AMMD
bac  Burkholderia ambifaria MC40-6
bmj  Burkholderia multivorans ATCC 17616 (Tohoku)
bmu  Burkholderia multivorans ATCC 17616 (JGI)
bmk  Burkholderia multivorans DDS 15A-1
bmul  Burkholderia multivorans ATCC BAA-247
bct  Burkholderia cepacia GG4
bced  Burkholderia cepacia DDS 7H-2
bcep  Burkholderia cepacia ATCC 25416
bdl  Burkholderia dolosa
bpyr  Burkholderia pyrrocinia
bcon  Burkholderia contaminans
bub  Burkholderia ubonensis
bdf  Burkholderia diffusa
blat  Burkholderia latens
btei  Burkholderia territorii
bsem  Burkholderia seminalis
bpsl  Burkholderia pseudomultivorans
bmec  Burkholderia metallica
bstg  Burkholderia stagnalis
bstl  Burkholderia stabilis
bann  Burkholderia anthina
bari  Burkholderia arboris
baen  Burkholderia aenigmatica
bser  Burkholderia semiarida
buk  Burkholderia sp. KJ006
burk  Burkholderia sp. JP2-270
burm  Burkholderia sp. MS389
burf  Burkholderia sp. FERM BP-3421
buv  Burkholderia sp. MS455
axy  Achromobacter xylosoxidans A8
axo  Achromobacter xylosoxidans NH44784-1996
axn  Achromobacter xylosoxidans NBRC 15126 = ATCC 27061
axx  Achromobacter xylosoxidans NCTC10807
adt  Achromobacter denitrificans
ais  Achromobacter insolitus
achr  Achromobacter sp. AONIH1
apes  Achromobacter pestifer
aaeg  Achromobacter aegrifaciens
asel  Achromobacter seleniivolatilans
achh  Achromobacter sp. HNDS-1
neu  Nitrosomonas europaea
mfa  Methylobacillus flagellatus
mmb  Methylotenera mobilis
mei  Methylovorus glucosotrophus
meu  Methylophilus sp. TWE2
mmec  Methylophilus medardicus
medz  Methylophilus sp. DW102
agl  Akkermansia glycaniphila
 » show all
Reference
PMID:15105137
  Authors
Llanes C, Hocquet D, Vogne C, Benali-Baitich D, Neuwirth C, Plesiat P
  Title
Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.
  Journal
Antimicrob Agents Chemother 48:1797-802 (2004)
DOI:10.1128/AAC.48.5.1797-1802.2004
Reference
PMID:10952562
  Authors
Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T
  Title
Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 44:2242-6 (2000)
DOI:10.1128/AAC.44.9.2242-2246.2000
Reference
PMID:21149619
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
PMID:19589837
  Authors
Yamamoto M, Ueda A, Kudo M, Matsuo Y, Fukushima J, Nakae T, Kaneko T, Ishigatsubo Y
  Title
Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa.
  Journal
Microbiology 155:3312-21 (2009)
DOI:10.1099/mic.0.028993-0
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