KEGG   MODULE: M00651
Entry
M00651            Signature Module                                 
Name
Vancomycin resistance, D-Ala-D-Lac type
Definition
(K18345 K18344 K07260 K18346),(K18351 K18352 K18354 K18353) (K18347 K15739 K08641)
Diagram
M00651  Vancomycin resistance, D-Ala-D-Lac type
M00651

Class
Signature modules; Gene set; Drug resistance
Pathway
map01502  Vancomycin resistance
map02020  Two-component system
Orthology
K18345  
vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
K18344  
vanRB; two-component system, OmpR family, response regulator VanR
K07260  
vanY; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4]
K18346  
vanW; vancomycin resistance protein VanW
K18351  
vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
K18352  
vanRAc; two-component system, OmpR family, response regulator VanR
K18354  
vanK; vancomycin resistance protein VanK
K18353  
vanJ; vancomycin resistance protein VanJ
K18347  
vanH; D-specific alpha-keto acid dehydrogenase [EC:1.1.1.-]
K15739  
vanB; D-alanine---(R)-lactate ligase [EC:6.1.2.1]
K08641  
vanX; D-alanyl-D-alanine dipeptidase [EC:3.4.13.22]
Complete
pson  Paenibacillus sonchi
efa  Enterococcus faecalis V583
efc  Enterococcus faecium Aus0004
efau  Enterococcus faecium Aus0085
sco  Streptomyces coelicolor
sroi  Streptomyces roseirectus
sspn  Streptomyces spinosirectus
kbu  Streptomyces sp. NL15-2K
kch  Kitasatospora cathayae
Reference
PMID:22913355
  Authors
Chancey ST, Zahner D, Stephens DS
  Title
Acquired inducible antimicrobial resistance in Gram-positive bacteria.
  Journal
Future Microbiol 7:959-78 (2012)
DOI:10.2217/fmb.12.63
Reference
PMID:8631706
  Authors
Evers S, Courvalin P
  Title
Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.
  Journal
J Bacteriol 178:1302-9 (1996)
DOI:10.1128/JB.178.5.1302-1309.1996
Reference
PMID:15130128
  Authors
Hong HJ, Hutchings MI, Neu JM, Wright GD, Paget MS, Buttner MJ
  Title
Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.
  Journal
Mol Microbiol 52:1107-21 (2004)
DOI:10.1111/j.1365-2958.2004.04032.x
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