KEGG   MODULE: M00661
Entry
M00661            Pathway   Module                                 
Name
Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Definition
K18385 K18386 K18387
Diagram
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
M00661

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other fungal compounds
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K18385  
geranylgeranyldiphosphate transferase [RN:R10349]
K18386  
FAD dependent monooxygenase [EC:1.14.13.-] [RN:R10350 R10351]
K18387  
paspaline synthase [RN:R10352 R10353]
Complete
maw  Metarhizium acridum
maj  Metarhizium robertsii
mbrn  Metarhizium brunneum
aor  Aspergillus oryzae
ang  Aspergillus niger (black aspergilli)
afv  Aspergillus flavus
aluc  Aspergillus luchuensis
apuu  Aspergillus puulaauensis
Reaction
Compound
C00353  Geranylgeranyl diphosphate
C03506  Indoleglycerol phosphate
C20525  3-Geranylgeranylindole
C20526  10,11-Epoxy-3-geranylgeranylindole
C20527  Emindole SB
C20529  14,15-Epoxyemindole SB
C20530  Paspaline
Reference
  Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
  Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
  Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:10.1021/ja3116636
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