Entry Name Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon
Definition K19077 K19078 K03367+K03739+K14188+K03740
Diagram Orthology graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:
2.7.13.3 ] [COG:
COG0642 ] [GO:
0000155 ]
graR; two-component system, OmpR family, response regulator protein GraR [COG:
COG0745 ] [GO:
0000156 ]
dltB; membrane protein involved in D-alanine export [COG:
COG1696 ]
dltD; D-alanine transfer protein [COG:
COG3966 ]
Ortholog table Taxonomy Class Signature modules; Gene set; Drug resistanceBRITE hierarchy
Pathway map01503 Cationic antimicrobial peptide (CAMP) resistance
Comment Resistance mechanism: addition of alanine to teichoic acids
Reference Authors Falord M, Karimova G, Hiron A, Msadek T
Title GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus.
Journal Reference Authors Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL
Title The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.
Journal Reference Authors Otto M
Title Staphylococcus epidermidis--the 'accidental' pathogen.
Journal Reference Authors Falord M, Mader U, Hiron A, Debarbouille M, Msadek T
Title Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways.
Journal LinkDB All DBs
