Entry Name Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF
Definition Diagram M00726 Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF
Class Signature modules; Gene set; Drug resistanceBRITE hierarchy
Pathway map01503 Cationic antimicrobial peptide (CAMP) resistance
Orthology graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:
2.7.13.3 ] [COG:
COG0642 ] [GO:
0000155 ]
graR; two-component system, OmpR family, response regulator protein GraR [COG:
COG0745 ] [GO:
0000156 ]
Ortholog table Taxonomy Complete sdo Sulfitobacter donghicola
sau Staphylococcus aureus subsp. aureus N315 (MRSA/VSSA)
sav Staphylococcus aureus subsp. aureus Mu50 (MRSA/VISA)
saw Staphylococcus aureus subsp. aureus Mu3 (MRSA/hetero-VISA)
sah Staphylococcus aureus subsp. aureus JH1 (MRSA/VSSA)
saj Staphylococcus aureus subsp. aureus JH9 (MRSA/VISA)
sam Staphylococcus aureus subsp. aureus MW2 (CA-MRSA)
sas Staphylococcus aureus subsp. aureus MSSA476 (MSSA)
sar Staphylococcus aureus subsp. aureus MRSA252 (MRSA)
sac Staphylococcus aureus subsp. aureus COL (MRSA)
sax Staphylococcus aureus subsp. aureus USA300_TCH1516 (CA-MRSA)
saa Staphylococcus aureus subsp. aureus USA300_FPR3757 (CA-MRSA)
sao Staphylococcus aureus subsp. aureus NCTC8325
sae Staphylococcus aureus subsp. aureus Newman
sad Staphylococcus aureus subsp. aureus ED98
suu Staphylococcus aureus subsp. aureus M013 (CA-MRSA)
suv Staphylococcus aureus subsp. aureus VC40
sue Staphylococcus aureus subsp. aureus ED133
suj Staphylococcus aureus subsp. aureus JKD6159 (CA-MRSA)
suk Staphylococcus aureus subsp. aureus JKD6008 (MRSA/VISA)
suc Staphylococcus aureus subsp. aureus ECT-R 2 (MSSA)
sut Staphylococcus aureus subsp. aureus T0131 (MRSA)
suq Staphylococcus aureus subsp. aureus TCH60
suz Staphylococcus aureus subsp. aureus 11819-97 (CA-MRSA)
sud Staphylococcus aureus subsp. aureus 71193 (MSSA)
sux Staphylococcus aureus subsp. aureus HO 5096 0412 (MRSA)
suw Staphylococcus aureus subsp. aureus TW20 (MRSA)
sug Staphylococcus aureus subsp. aureus ST398 (MRSA)
suf Staphylococcus aureus subsp. aureus LGA251 (MRSA)
saua Staphylococcus aureus subsp. aureus 55/2053
saue Staphylococcus aureus subsp. aureus 6850 (MSSA)
saun Staphylococcus aureus subsp. aureus CN1 (CA-MRSA)
saus Staphylococcus aureus subsp. aureus SA40 (CA-MRSA)
sauu Staphylococcus aureus subsp. aureus SA957 (CA-MRSA)
saug Staphylococcus aureus subsp. aureus SA268 (CA-MRSA)
sauz Staphylococcus aureus subsp. aureus Z172 (MRSA/VISA)
saut Staphylococcus aureus subsp. aureus ST228/10388 (MRSA)
sauj Staphylococcus aureus subsp. aureus ST228/10497 (MRSA)
sauk Staphylococcus aureus subsp. aureus ST228/15532 (MRSA)
sauq Staphylococcus aureus subsp. aureus ST228/16035 (MRSA)
sauv Staphylococcus aureus subsp. aureus ST228/18412 (MRSA)
sauw Staphylococcus aureus subsp. aureus ST228/16125 (MRSA)
saux Staphylococcus aureus subsp. aureus ST228/18341 (MRSA)
sauy Staphylococcus aureus subsp. aureus ST228/18583 (MRSA)
sauf Staphylococcus aureus subsp. aureus FDAARGOS_5
sab Staphylococcus aureus RF122
suy Staphylococcus aureus 04-02981 (MRSA)
saub Staphylococcus aureus 08BA02176 (LA-MRSA)
saum Staphylococcus aureus M1 (MRSA)
sauc Staphylococcus aureus CA-347 (MRSA)
saur Staphylococcus aureus Bmb9393 (MRSA)
saui Staphylococcus aureus USA300-ISMMS1 (MRSA)
saud Staphylococcus aureus 502A
sams Staphylococcus aureus MS4
suh Staphylococcus argenteus
ser Staphylococcus epidermidis RP62A (MRSE)
sep Staphylococcus epidermidis ATCC 12228
sepp Staphylococcus epidermidis PM221
seps Staphylococcus epidermidis SEI
sha Staphylococcus haemolyticus JCSC1435
shh Staphylococcus haemolyticus Sh29/312/L2
ssp Staphylococcus saprophyticus
sca Staphylococcus carnosus subsp. carnosus
slg Staphylococcus lugdunensis HKU09-01
sln Staphylococcus lugdunensis N920143
ssd Staphylococcus pseudintermedius HKU10-03
sdt Staphylococcus pseudintermedius ED99
sdp Staphylococcus delphini
swa Staphylococcus warneri
spas Staphylococcus pasteuri
sxy Staphylococcus xylosus HKUOPL8
sxl Staphylococcus xylosus SMQ-121
sxo Staphylococcus xylosus C2a
scap Staphylococcus capitis subsp. capitis
ssch Staphylococcus schleiferi 1360-13
sscz Staphylococcus schleiferi 2317-03
seqo Staphylococcus equorum
ssif Staphylococcus simulans
slz Staphylococcus lutrae
sury Staphylococcus ureilyticus
snl Staphylococcus nepalensis
skl Staphylococcus kloosii
shom Staphylococcus hominis
smus Staphylococcus muscae
scar Staphylococcus caprae
sarl Staphylococcus arlettae
spic Staphylococcus piscifermentans
ssh Staphylococcus schweitzeri
ssim Staphylococcus simiae
sllo Staphylococcus lloydii
ssac Staphylococcus saccharolyticus
spsd Staphylococcus shinii
stas Staphylococcus taiwanensis
seda Staphylococcus edaphicus
sdev Staphylococcus devriesei
srot Staphylococcus roterodami
stap Staphylococcus sp. AntiMn-1
sgai Staphylococcus gallinarum
ssuc Staphylococcus succinus
sscu Mammaliicoccus sciuri
sff Mammaliicoccus fleurettii
sste Mammaliicoccus stepanovicii
mlen Mammaliicoccus lentus
mvt Mammaliicoccus vitulinus
» show all Comment Resistance mechanism: addition of lysine to phospholipids
Reference Authors Falord M, Karimova G, Hiron A, Msadek T
Title GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus.
Journal Reference Authors Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL
Title The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.
Journal Reference Authors Otto M
Title Staphylococcus epidermidis--the 'accidental' pathogen.
Journal LinkDB All DBs
