Entry Name Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF
Definition Diagram Orthology graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:
2.7.13.3 ] [COG:
COG0642 ] [GO:
0000155 ]
graR; two-component system, OmpR family, response regulator protein GraR [COG:
COG0745 ] [GO:
0000156 ]
Ortholog table Taxonomy Class Signature modules; Gene set; Drug resistanceBRITE hierarchy
Pathway map01503 Cationic antimicrobial peptide (CAMP) resistance
Comment Resistance mechanism: addition of lysine to phospholipids
Reference Authors Falord M, Karimova G, Hiron A, Msadek T
Title GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus.
Journal Reference Authors Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL
Title The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.
Journal Reference Authors Otto M
Title Staphylococcus epidermidis--the 'accidental' pathogen.
Journal LinkDB All DBs
