MODULE: M00763
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Entry
M00763 Pathway Module
Name
Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
Definition
K05826
K19412 K05828 K05829 K05830 K05831
Diagram
Orthology
K05826
glutamate carrier protein LysW
K19412
glutamate--LysW ligase ArgX [EC:6.3.2.-] [RN:
R10929
]
K05828
LysW-L-glutamate kinase [EC:
2.7.2.19
] [RN:
R10930
]
K05829
LysW-L-glutamyl-5-phosphate reductase [EC:1.2.1.-] [RN:
R10931
]
K05830
LysW-L-ornithine aminotransferase [EC:
2.6.1.124
] [RN:
R10932
]
K05831
LysW-L-ornithine hydrolase [EC:
3.5.1.132
] [RN:
R10933
]
Ortholog table
Taxonomy
Class
Pathway modules; Amino acid metabolism; Arginine and proline metabolism
BRITE hierarchy
Pathway
map00220
Arginine biosynthesis
map01210
2-Oxocarboxylic acid metabolism
map01230
Biosynthesis of amino acids
map01100
Metabolic pathways
Reaction
R10929
C00025
->
C20948
R10930
C20948
->
C20949
R10931
C20949
->
C20950
R10932
C20950
->
C20951
R10933
C20951
->
C00077
Compound
C00025
L-Glutamate
C20948
LysW-L-glutamate
C20949
LysW-L-glutamyl 5-phosphate
C20950
LysW-L-glutamate 5-semialdehyde
C20951
LysW-L-ornithine
C00077
L-Ornithine
RModule
RM002
Carboxyl to amino conversion using protective N-acetyl group (basic amino acid synthesis)
Reference
PMID:
23434852
Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Journal
Nat Chem Biol 9:277-83 (2013)
DOI:
10.1038/nchembio.1200
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