Entry
Name
Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Definition
K19969 K20431 K20432 K20433 K20434 K20435 K20436 K20437 K20438
Diagram
Orthology
valK; 5-epi-valiolone dehydratase [EC:4.2.1.-] [RN:
R11233 ]
valC; C7-cyclitol kinase [EC:2.7.1.-] [RN:
R11234 ]
valN; cyclitol reductase [RN:
R11236 ]
valM; validone 7-phosphate aminotransferase [EC2.6.1.-] [RN:
R11238 ]
valL; validoxylamine A 7'-phosphate synthase [EC:2.4.1.-] [RN:
R11497 ]
Ortholog table Taxonomy
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
BRITE hierarchy
Pathway
map00525 Acarbose and validamycin biosynthesis
map01110 Biosynthesis of secondary metabolites
Reaction
Compound
C20956 alpha-D-Sedoheptulopyranose 7-phosphate
C21219 Validoxylamine A 7'-phosphate
Reference
Authors
Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z
Title
Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
Journal
Reference
Authors
Singh D, Seo MJ, Kwon HJ, Rajkarnikar A, Kim KR, Kim SO, Suh JW
Title
Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704).
Journal
Reference
Authors
Deng Z, Bai L
Title
Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.
Journal
Reference
Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
Journal
LinkDB
All DBs