Entry Name Prodigiosin biosynthesis, L-proline => prodigiosin
Definition K21780+K21781 K21782 K21783 K21784 K21785 K21786
Diagram Orthology pigI; L-proline---[L-prolyl-carrier protein] ligase [EC:
6.2.1.53 ] [RN:
R06746 ]
pigG; peptidyl carrier protein [RN:
R06746 ]
pigJ; beta-ketoacyl ACP synthase [EC:2.3.1.-] [RN:
R11665 ]
pigH; 4-hydroxy-2,2'-bipyrrole-5-methanol synthase [RN:
R11667 ]
pigM; 4-hydroxy-2,2'-bipyrrole-5-methanol dehydrogenase [RN:
R11668 R11669 ]
pigF; 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde O-methyltransferase [EC:2.1.1.-] [RN:
R11670 ]
pigE; 3-acetyloctanal aminotransferase [EC:2.6.1.-] [RN:
R11672 ]
pigB; 2-methyl-3-n-amyl-dihydropyrrolel dehydrogenase [RN:
R11661 ]
pigC; prodigiosin/undecylprodigiosin synthetase [RN:
R11662 ]
Ortholog table Taxonomy Class Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compoundsBRITE hierarchy
Pathway map01110 Biosynthesis of secondary metabolites
Reaction Compound C12483 Pyrrole-2-carbonyl-[pcp]
C21567 Pyrrolyl-2-carboxyl-S-[acyl-carrier protein]
C21568 4-Hydroxy-2,2'-bipyrrole-5-methanol
C21569 4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde
C21570 4-Methoxy-2,2'-bipyrrole-5-carbaldehyde
C21571 2-Methyl-3-n-amyl-dihydropyrrole
C21572 2-Methyl-3-n-amyl-pyrrole
Reference Authors Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP
Title Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
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