KEGG   MODULE: M00906
Entry
M00906            Pathway   Module                                 
Name
Ethynylserine biosynthesis, lysine => ethynylserine
Definition
K23669 K23670 K23671 K23672 K23673
Diagram
M00906  Ethynylserine biosynthesis, lysine => ethynylserine
M00906

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K23669  
besD; L-lysine 4-chlorinase [EC:1.14.20.-] [RN:R12407]
K23670  
besC; 4-chloro-allylglycine synthase [EC:1.14.99.-] [RN:R12408]
K23671  
besB; L-2-amino-4-chloropent-4-enoate dechlorinase/desaturase [EC:4.5.1.-] [RN:R12409]
K23672  
besA; L-propargylglycine--L-glutamate ligase [EC:6.3.2.-] [RN:R12410]
K23673  
besE; L-gamma-glutamyl-L-propargylglycine hydroxylase [EC:1.14.11.-] [RN:R12411]
Complete
sct  Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488
scy  Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488
Reaction
R12407  
R12408  
R12409  
R12410  
R12411  
R12412  
Compound
C00047  L-Lysine
C22137  4-Chloro-L-lysine
C04075  2-Amino-4-chloro-4-pentenoic acid
C22138  L-Propargylglycine
C22139  gamma-L-Glutamyl-L-propargylglycine
C22140  L-gamma-Glutamyl-(3R)-L-beta-ethynylserine
C22141  L-beta-Ethynylserine
Reference
PMID:30867596
  Authors
Marchand JA, Neugebauer ME, Ing MC, Lin CI, Pelton JG, Chang MCY
  Title
Discovery of a pathway for terminal-alkyne amino acid biosynthesis.
  Journal
Nature 567:420-424 (2019)
DOI:10.1038/s41586-019-1020-y
LinkDB

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