KEGG   MODULE: M00921
Entry
M00921            Pathway   Module                                 
Name
Cyclooctatin biosynthesis, dimethylallyl-PP + isopentenyl-PP => cyclooctatin
Definition
K13787 K18686 K22997 K22998
Diagram
M00921

Orthology
K13787  
cotB1; geranylgeranyl diphosphate synthase [EC:2.5.1.1 2.5.1.10 2.5.1.29] [RN:R01658 R02003 R02061]
K18686  
cotB2; cyclooctat-9-en-7-ol synthase [EC:4.2.3.146] [RN:R10763]
K22997  
cotB3; cyclooctat-9-en-7-ol 5-monooxygenase [EC:1.14.99.61] [RN:R12177]
K22998  
cotB4; cyclooctatin synthase [EC:1.14.99.62] [RN:R12178]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00900  Terpenoid backbone biosynthesis
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00235  Dimethylallyl diphosphate
C00129  Isopentenyl diphosphate
C00341  Geranyl diphosphate
C00448  trans,trans-Farnesyl diphosphate
C00353  Geranylgeranyl diphosphate
C20834  Cyclooctat-9-en-7-ol
C21978  Cyclooctat-9-ene-5,7-diol
C21979  Cyclooctatin
Reference
  Authors
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  Title
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  Journal
Chem Biol 16:736-43 (2009)
DOI:10.1016/j.chembiol.2009.06.007
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