KEGG   MODULE: M00962
Entry
M00962            Pathway   Module                                 
Name
Psilocybin biosynthesis, tryptophan => psilocybin
Definition
K22433 K22434 K22435 K22436
Diagram
M00962  Psilocybin biosynthesis, tryptophan => psilocybin
M00962

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K22433  
PSID; L-tryptophan decarboxylase [EC:4.1.1.105] [RN:R00685]
K22434  
PSIH; tryptamine 4-monooxygenase [EC:1.14.99.59] [RN:R11912]
K22435  
PSIK; 4-hydroxytryptamine kinase [EC:2.7.1.222] [RN:R11933 R08480]
K22436  
PSIM; psilocybin synthase [EC:2.1.1.345] [RN:R11935 R11936]
Complete
pcub  Psilocybe cubensis (magic mushroom)
181762  Psilocybe cubensis
Reaction
R00685  
R11912  
R11933  
R11935  
R11936  
R12142  
R08480  
Compound
C00078  L-Tryptophan
C00398  Tryptamine
C21762  4-Hydroxytryptamine
C21778  Norbaeocystin
C21779  Baeocystin
C07576  Psilocybin
C08312  Psilocin
Reference
PMID:28763571
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
LinkDB

DBGET integrated database retrieval system