KEGG   MODULE: M00964
Entry
M00964            Pathway   Module                                 
Name
Fumigaclavine biosynthesis, chanoclavine-I aldehyde => fumigaclavine C
Definition
K19182 K19183 -- K19184 K14135
Diagram
M00964  Fumigaclavine biosynthesis, chanoclavine-I aldehyde => fumigaclavine C
M00964

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K19182  
FGAOX3; chanoclavine-I aldehyde reductase [EC:1.3.1.100] [RN:R12090]
K19183  
FGAFS; festuclavine dehydrogenase [EC:1.5.1.44] [RN:R10163]
K19184  
FGAAT; fumigaclavine B O-acetyltransferase [EC:2.3.1.205] [RN:R10200]
K14135  
FGAPT1; fumigaclavine A dimethylallyltransferase [EC:2.5.1.100] [RN:R10201]
Complete
afm  Aspergillus fumigatus
Reaction
R12090  
R12091  
R10163  
R12093  
R10200  
R10201  
Compound
C20379  Chanoclavine-I aldehyde
C21897  Dihydrochanoclavine-I aldehyde
C20409  6,8-Dimethyl-6,7-didehydroergoline
C20408  Festuclavine
C20437  Fumigaclavine B
C20436  Fumigaclavine A
C20438  Fumigaclavine C
Reference
PMID:20526482
  Authors
Wallwey C, Matuschek M, Xie XL, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
  Journal
Org Biomol Chem 8:3500-8 (2010)
DOI:10.1039/c003823g
Reference
PMID:19672909
  Authors
Liu X, Wang L, Steffan N, Yin WB, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B.
  Journal
Chembiochem 10:2325-8 (2009)
DOI:10.1002/cbic.200900395
LinkDB

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