KEGG   MODULE: M00971
Entry
M00971            Pathway   Module                                 
Name
QS-7 biosynthesis, 2,3-epoxysqualene => QS-7
Definition
K15813 K20667 K26481 K26482 K26483 K26484 K26485 (K26487+K26488) K26489 K26490 K26491 (K26493+K26494+K26495)
Diagram
M00971  QS-7 biosynthesis, 2,3-epoxysqualene => QS-7
M00971

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K15813  
beta-amyrin synthase [EC:5.4.99.39] [RN:R06469]
K20667  
beta-amyrin 28-monooxygenase [EC:1.14.14.126] [RN:R10924]
K26481  
oleanolic acid C16alpha-oxidase [RN:R13149]
K26482  
echinocystic acid C23-oxidase [RN:R13150]
K26483  
quillaic acid 3-O-glucuronosyltransferase [RN:R13151]
K26484  
quillaic acid 3-O-GlcA beta-1,2-galactosyltransferase [EC:2.4.1.-] [RN:R13152]
K26485  
quillaic acid 3-O-Gal-1,2-GlcA beta-1,3-xylosyltransferase [EC:2.4.2.-] [RN:R13153]
K26487  
quillaic acid 3-O-Xyl/L-Rha-1,3-(Gal-1,2)-GlcA 28-O-glycosyltransferase [RN:R13155]
K26488  
4-keto-6-deoxyglucose 4-dehydrogenase [RN:R13155]
K26489  
quillaic acid 3-O-Xyl/L-Rha-1,3-(Gal-1,2)-GlcA-28-O-Fuc alpha-1,2-rhamnosyltransferase [EC:2.4.1.-] [RN:R13157]
K26490  
quillaic acid 3-O-Xyl/L-Rha-1,3-(Gal-1,2)-GlcA-28-O-L-Rha-1,2-Fuc beta-1,4-xylosyltransferase [EC:2.4.2.-] [RN:13159]
K26491  
quillaic acid 3-O-Xyl/L-Rha-1,3-(Gal-1,2)-GlcA-28-O-Xyl-1,4-L-Rha-1,2-Fuc beta-1,3-apiosyltransferase [EC:2.4.2.-] [RN:13162]
K26493  
O-acetyltransferase [RN:R13165]
K26494  
alpha-1,3-rhamnosyltransferase [EC:2.4.1.-] [RN:R13165]
K26495  
beta-1,3-glucosyltransferase [EC:2.4.1.-] [RN:R13165]
Complete
qsa  Quillaja saponaria (soapbark tree)
Reaction
R06469  
R10924  
R13149  
R13150  
R13151  
R13152  
R13153  
R13155  
R13157  
R13159  
R13162  
R13165  
Compound
C01054  (S)-2,3-Epoxysqualene
C08616  beta-Amyrin
C17148  Oleanolic acid
C08942  Echinocystic acid
C08972  Quillaic acid
C22652  Quillaic acid 3-O-beta-D-glucuronide
C22653  Quillaic acid 3-O-beta-D-galactosyl-1,2-beta-D-glucuronide
C22654  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22656  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22658  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22660  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22664  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22666  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide 28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-(beta-D-glucosyl-1,3)-alpha-L-rhamnosyl-1,2-(alpha-L-rhamnosyl-1,3)-4-O-acetyl-beta-D-fucoside
Reference
PMID:36952412
  Authors
Reed J, Orme A, El-Demerdash A, Owen C, Martin LBB, Misra RC, Kikuchi S, Rejzek M, Martin AC, Harkess A, Leebens-Mack J, Louveau T, Stephenson MJ, Osbourn A.
  Title
Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree.
  Journal
Science 379:1252-1264 (2023)
DOI:10.1126/science.adf3727
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