KEGG   NETWORK: N00050
Entry
N00050                      Network                                
Name
Amplified PI3K to PI3K signaling pathway
Definition
PI3K* -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
5290v2 -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06270 Breast cancer
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05224  Breast cancer
Disease
H00031  Breast cancer
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Variant
5290v2 (PI3K*)  PIK3CA amplification
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
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