| Entry |
|
|---|
| Name |
BCR-ABL fusion kinase to Jak-STAT signaling pathway
|
|---|
| Definition |
BCR-ABL -> STAT5 => BCL2L1 |
|---|
| Expanded |
(25v1,25v2) -> (6776,6777) => 598 |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
| H00004 | Chronic myeloid leukemia |
|
|---|
| Gene |
| 25 | ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase |
| 6776 | STAT5A; signal transducer and activator of transcription 5A |
| 6777 | STAT5B; signal transducer and activator of transcription 5B |
|
|---|
| Variant |
25v1 (BCR-ABL) BCR-ABL1 fusion
25v2 (BCR-ABL) First generation TKI-resistant ABL1 mutation
|
|---|
| Reference |
|
|---|
| Authors |
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. |
|---|
| Title |
The biology of chronic myeloid leukemia. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Deininger MW, Goldman JM, Melo JV. |
|---|
| Title |
The molecular biology of chronic myeloid leukemia. |
|---|
| Journal |
Blood 96:3343-56 (2000) |
|---|
| Reference |
|
|---|
| Authors |
Calabretta B, Perrotti D. |
|---|
| Title |
The biology of CML blast crisis. |
|---|
| Journal |
|
|---|
| LinkDB |
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