KEGG T01001: 598

Homo sapiens (human): 598

Entry

598               CDS       T01001

Symbol

BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52

Name

(RefSeq) BCL2 like 1

K04570

Bcl-2-like 1 (apoptosis regulator Bcl-X)

Organism

hsa Homo sapiens (human)

Pathway

hsa01521

EGFR tyrosine kinase inhibitor resistance

hsa01524

Platinum drug resistance

hsa04014

Ras signaling pathway

hsa04064

NF-kappa B signaling pathway

hsa04115

p53 signaling pathway

hsa04137

Mitophagy - animal

hsa04140

Autophagy - animal

hsa04151

PI3K-Akt signaling pathway

hsa04210

Apoptosis

hsa04215

Apoptosis - multiple species

hsa04621

NOD-like receptor signaling pathway

hsa04630

JAK-STAT signaling pathway

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05131

Shigellosis

hsa05145

Toxoplasmosis

hsa05162

Measles

hsa05166

Human T-cell leukemia virus 1 infection

hsa05168

Herpes simplex virus 1 infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05212

Pancreatic cancer

hsa05220

Chronic myeloid leukemia

hsa05222

Small cell lung cancer

hsa05225

Hepatocellular carcinoma

hsa05417

Lipid and atherosclerosis

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06219  JAK-STAT signaling (cancer)
nt06231  Apoptosis (cancer)
nt06240  Transcription (cancer)
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis

Element

N00055

BCR-ABL fusion kinase to Jak-STAT signaling pathway

N00098

Intrinsic apoptotic pathway

N00123

Amplified REL to transcription

N00451

HIV Tat to intrinsic apoptotic pathway

N01051

Mutation-inactivated DJ1 to intrinsic apoptotic pathway

Drug target

Navitoclax (DG03204):

D09935 D09936

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    598 (BCL2L1)
   04630 JAK-STAT signaling pathway
    598 (BCL2L1)
   04064 NF-kappa B signaling pathway
    598 (BCL2L1)
   04151 PI3K-Akt signaling pathway
    598 (BCL2L1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    598 (BCL2L1)
   04137 Mitophagy - animal
    598 (BCL2L1)
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    598 (BCL2L1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    598 (BCL2L1)
   05202 Transcriptional misregulation in cancer
    598 (BCL2L1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    598 (BCL2L1)
   05225 Hepatocellular carcinoma
    598 (BCL2L1)
   05220 Chronic myeloid leukemia
    598 (BCL2L1)
   05222 Small cell lung cancer
    598 (BCL2L1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    598 (BCL2L1)
   05170 Human immunodeficiency virus 1 infection
    598 (BCL2L1)
   05162 Measles
    598 (BCL2L1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    598 (BCL2L1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    598 (BCL2L1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    598 (BCL2L1)
   05014 Amyotrophic lateral sclerosis
    598 (BCL2L1)
   05022 Pathways of neurodegeneration - multiple diseases
    598 (BCL2L1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    598 (BCL2L1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    598 (BCL2L1)
   01524 Platinum drug resistance
    598 (BCL2L1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    598 (BCL2L1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    598 (BCL2L1)
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    598 (BCL2L1)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     598 (BCL2L1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    598 (BCL2L1)
Transporters [BR:hsa02000]
Other transporters
  Pores ion channels [TC:1]
   598 (BCL2L1)

SSDB

Motif

Pfam:

Bcl-2 BH4 Bcl-2_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

20:complement(31664452..31723963)

AA seq 233 aa
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

NT seq 702 nt +upstreamnt +downstreamnt
atgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaa
ggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaaggg
actgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggca
gacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtg
atccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcgg
taccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatat
cagagctttgaacaggtagtgaatgaactcttccgggatggggtaaactggggtcgcatt
gtggcctttttctccttcggcggggcactgtgcgtggaaagcgtagacaaggagatgcag
gtattggtgagtcggatcgcagcttggatggccacttacctgaatgaccacctagagcct
tggatccaggagaacggcggctgggatacttttgtggaactctatgggaacaatgcagca
gccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtg
gccggcgtggttctgctgggctcactcttcagtcggaaatga

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