KEGG   NETWORK: N00066
Entry
N00066                      Network                                
Name
MDM2-p21-Cell cycle G1/S
Definition
CDKN2A -| MDM2 -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
1029 -| 4193 -| 7157 => 1026 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06263 Hepatocellular carcinoma
nt06265 Bladder cancer
nt06266 Non-small cell lung cancer
nt06268 Melanoma
nt06270 Breast cancer
nt06273 Glioma
nt06276 Chronic myeloid leukemia
nt06230 Cell cycle (cancer)
nt06163 Hepatitis C virus (HCV)
nt06170 Influenza A virus (IAV)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
4193  MDM2; MDM2 proto-oncogene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:25609713
  Authors
Shaltiel IA, Krenning L, Bruinsma W, Medema RH
  Title
The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.
  Journal
J Cell Sci 128:607-20 (2015)
DOI:10.1242/jcs.163766
Reference
PMID:9417035
  Authors
Agarwal ML, Taylor WR, Chernov MV, Chernova OB, Stark GR
  Title
The p53 network.
  Journal
J Biol Chem 273:1-4 (1998)
DOI:10.2152/jmi.51.146
Reference
PMID:23226679
  Authors
Chen L, Tweddle DA
  Title
p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.
  Journal
Front Oncol 2:173 (2012)
DOI:10.3389/fonc.2012.00173
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