Entry
Symbol
CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Name
(RefSeq) cyclin dependent kinase inhibitor 1A
KO
K06625 cyclin-dependent kinase inhibitor 1A
Organism
Pathway
hsa04928 Parathyroid hormone synthesis, secretion and action
hsa05163 Human cytomegalovirus infection
hsa05166 Human T-cell leukemia virus 1 infection
hsa05167 Kaposi sarcoma-associated herpesvirus infection
hsa05202 Transcriptional misregulation in cancer
Network
Element
N00066 MDM2-p21-Cell cycle G1/S
N00067 Deleted p14(ARF) to p21-cell cycle G1/S
N00068 Amplified MDM2 to p21-cell cycle G1/S
N00076 Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00115 Mutation-inactivated TP53 to transcription
N00127 PRCC-TFE3 fusion to transcriptional activation
N00134 EWSR1-FLI1 fusion to transcriptional repression
N00223 EBV EBNA1 to p53-mediated transcription
N00263 EBV EBNA3C to p53-mediated transcription
N00347 p300-p21-Cell cycle G1/S
N00359 HPV E7 to p27-cell cycle G1/S
N00362 HPV E5 to p21-cell cycle G1/S
N00421 HCMV IE2-86 to p21-cell cycle G1/S
N00481 EBV BZLF1 to p53-mediated transcription
N00497 HTLV-1 Tax to p21-cell cycle G1/S
N00498 HTLV-1 Tax to p21-cell cycle G1/S
N00499 ATR-p21-Cell cycle G2/M
N00523 HCV Core to p21-cell cycle G1/S
N00535 HBV HBx to p53-mediated transcription
N00536 MDM2-p21-Cell cycle G1/S
Disease
Brite
KEGG Orthology (KO) [BR:hsa00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
1026 (CDKN1A)
04630 JAK-STAT signaling pathway
1026 (CDKN1A)
04066 HIF-1 signaling pathway
1026 (CDKN1A)
04068 FoxO signaling pathway
1026 (CDKN1A)
04151 PI3K-Akt signaling pathway
1026 (CDKN1A)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
1026 (CDKN1A)
04115 p53 signaling pathway
1026 (CDKN1A)
04218 Cellular senescence
1026 (CDKN1A)
09150 Organismal Systems
09152 Endocrine system
04921 Oxytocin signaling pathway
1026 (CDKN1A)
04928 Parathyroid hormone synthesis, secretion and action
1026 (CDKN1A)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1026 (CDKN1A)
05202 Transcriptional misregulation in cancer
1026 (CDKN1A)
05206 MicroRNAs in cancer
1026 (CDKN1A)
05205 Proteoglycans in cancer
1026 (CDKN1A)
05203 Viral carcinogenesis
1026 (CDKN1A)
09162 Cancer: specific types
05210 Colorectal cancer
1026 (CDKN1A)
05212 Pancreatic cancer
1026 (CDKN1A)
05225 Hepatocellular carcinoma
1026 (CDKN1A)
05226 Gastric cancer
1026 (CDKN1A)
05214 Glioma
1026 (CDKN1A)
05216 Thyroid cancer
1026 (CDKN1A)
05220 Chronic myeloid leukemia
1026 (CDKN1A)
05217 Basal cell carcinoma
1026 (CDKN1A)
05218 Melanoma
1026 (CDKN1A)
05211 Renal cell carcinoma
1026 (CDKN1A)
05219 Bladder cancer
1026 (CDKN1A)
05215 Prostate cancer
1026 (CDKN1A)
05213 Endometrial cancer
1026 (CDKN1A)
05224 Breast cancer
1026 (CDKN1A)
05222 Small cell lung cancer
1026 (CDKN1A)
05223 Non-small cell lung cancer
1026 (CDKN1A)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
1026 (CDKN1A)
05161 Hepatitis B
1026 (CDKN1A)
05160 Hepatitis C
1026 (CDKN1A)
05163 Human cytomegalovirus infection
1026 (CDKN1A)
05167 Kaposi sarcoma-associated herpesvirus infection
1026 (CDKN1A)
05169 Epstein-Barr virus infection
1026 (CDKN1A)
05165 Human papillomavirus infection
1026 (CDKN1A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
1026 (CDKN1A)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
1026 (CDKN1A)
01522 Endocrine resistance
1026 (CDKN1A)
BRITE hierarchy
SSDB
Ortholog Paralog Gene cluster GFIT
Motif
Motif
Other DBs
Structure
PDB
LinkDB
All DBs
Position
6:36676463..36687332
Genome browser
AA seq
164 aa AA seq DB search
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE
GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV
PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
NT seq
495 nt NT seq +upstream nt +downstream nt
atgtcagaaccggctggggatgtccgtcagaacccatgcggcagcaaggcctgccgccgc
ctcttcggcccagtggacagcgagcagctgagccgcgactgtgatgcgctaatggcgggc
tgcatccaggaggcccgtgagcgatggaacttcgactttgtcaccgagacaccactggag
ggtgacttcgcctgggagcgtgtgcggggccttggcctgcccaagctctaccttcccacg
gggccccggcgaggccgggatgagttgggaggaggcaggcggcctggcacctcacctgct
ctgctgcaggggacagcagaggaagaccatgtggacctgtcactgtcttgtacccttgtg
cctcgctcaggggagcaggctgaagggtccccaggtggacctggagactctcagggtcga
aaacggcggcagaccagcatgacagatttctaccactccaaacgccggctgatcttctcc
aagaggaagccctaa