KEGG   Homo sapiens (human): 1026Help
Entry
1026              CDS       T01001                                 

Gene name
CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Definition
(RefSeq) cyclin dependent kinase inhibitor 1A
  KO
K06625  cyclin-dependent kinase inhibitor 1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04630  Jak-STAT signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05217  Basal cell carcinoma
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00115  Mutation-inactivated TP53 to transcription
N00127  PRCC-TFE3 fusion to transcriptional activation
N00134  EWSR1-FLI1 fusion to transcriptional repression
N00167  KSHV vIRF1/3 to p21-cell cycle G1/S
N00169  KSHV LANA to p21-cell cycle G1/S
N00223  EBV EBNA1 to p53-mediated transcription
N00263  EBV EBNA3C to p53-mediated transcription
N00317  Aryl hydrocarbon receptor signaling pathway
N00347  p300-p21-Cell cycle G1/S
N00348  HPV E6 to p300-p21-Cell cycle G1/S
N00349  HPV E6 to p300-p21-Cell cycle G1/S
N00358  HPV E6 to p21-cell cycle G1/S
N00359  HPV E7 to p27-cell cycle G1/S
N00362  HPV E5 to p21-cell cycle G1/S
N00420  HCMV IE2-86 to p21-cell cycle G1/S
N00421  HCMV IE2-86 to p21-cell cycle G1/S
N00481  EBV BZLF1 to p53-mediated transcription
N00496  MDM2-p21-Cell cycle G1/S
N00497  HTLV-1 Tax to p21-cell cycle G1/S
N00498  HTLV-1 Tax to p21-cell cycle G1/S
N00499  ATR-p21-Cell cycle G2/M
N00520  HCV NS5A to p21-cell cycle G1/S
N00521  HCV Core to p21-cell cycle G1/S
N00522  HCV NS3 to p21-cell cycle G1/S
N00523  HCV Core to p21-cell cycle G1/S
N00535  HBV HBx to p53-mediated transcription
N00536  MDM2-p21-Cell cycle G1/S
 » show all
Disease
H00030  Cervical cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    1026 (CDKN1A)
   04630 Jak-STAT signaling pathway
    1026 (CDKN1A)
   04066 HIF-1 signaling pathway
    1026 (CDKN1A)
   04068 FoxO signaling pathway
    1026 (CDKN1A)
   04151 PI3K-Akt signaling pathway
    1026 (CDKN1A)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1026 (CDKN1A)
   04115 p53 signaling pathway
    1026 (CDKN1A)
   04218 Cellular senescence
    1026 (CDKN1A)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    1026 (CDKN1A)
   04928 Parathyroid hormone synthesis, secretion and action
    1026 (CDKN1A)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    1026 (CDKN1A)
   05202 Transcriptional misregulation in cancer
    1026 (CDKN1A)
   05206 MicroRNAs in cancer
    1026 (CDKN1A)
   05205 Proteoglycans in cancer
    1026 (CDKN1A)
   05203 Viral carcinogenesis
    1026 (CDKN1A)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    1026 (CDKN1A)
   05212 Pancreatic cancer
    1026 (CDKN1A)
   05225 Hepatocellular carcinoma
    1026 (CDKN1A)
   05226 Gastric cancer
    1026 (CDKN1A)
   05214 Glioma
    1026 (CDKN1A)
   05216 Thyroid cancer
    1026 (CDKN1A)
   05220 Chronic myeloid leukemia
    1026 (CDKN1A)
   05217 Basal cell carcinoma
    1026 (CDKN1A)
   05218 Melanoma
    1026 (CDKN1A)
   05211 Renal cell carcinoma
    1026 (CDKN1A)
   05219 Bladder cancer
    1026 (CDKN1A)
   05215 Prostate cancer
    1026 (CDKN1A)
   05213 Endometrial cancer
    1026 (CDKN1A)
   05224 Breast cancer
    1026 (CDKN1A)
   05222 Small cell lung cancer
    1026 (CDKN1A)
   05223 Non-small cell lung cancer
    1026 (CDKN1A)
  09167 Endocrine and metabolic diseases
   04934 Cushing syndrome
    1026 (CDKN1A)
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    1026 (CDKN1A)
   05161 Hepatitis B
    1026 (CDKN1A)
   05160 Hepatitis C
    1026 (CDKN1A)
   05163 Human cytomegalovirus infection
    1026 (CDKN1A)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1026 (CDKN1A)
   05169 Epstein-Barr virus infection
    1026 (CDKN1A)
   05165 Human papillomavirus infection
    1026 (CDKN1A)
  09176 Drug resistance: Antineoplastic
   01524 Platinum drug resistance
    1026 (CDKN1A)
   01522 Endocrine resistance
    1026 (CDKN1A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: CDI
Motif
Other DBs
NCBI-GeneID: 1026
NCBI-ProteinID: NP_000380
OMIM: 116899
HGNC: 1784
Ensembl: ENSG00000124762
Vega: OTTHUMG00000014603
Pharos: P38936(Tbio)
UniProt: P38936 A0A024RCX5
LinkDB All DBs
Structure
PDB: 

Position
6p21.2
AA seq 164 aa AA seqDB search
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE
GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV
PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
NT seq 495 nt NT seq  +upstreamnt  +downstreamnt
atgtcagaaccggctggggatgtccgtcagaacccatgcggcagcaaggcctgccgccgc
ctcttcggcccagtggacagcgagcagctgagccgcgactgtgatgcgctaatggcgggc
tgcatccaggaggcccgtgagcgatggaacttcgactttgtcaccgagacaccactggag
ggtgacttcgcctgggagcgtgtgcggggccttggcctgcccaagctctaccttcccacg
gggccccggcgaggccgggatgagttgggaggaggcaggcggcctggcacctcacctgct
ctgctgcaggggacagcagaggaagaccatgtggacctgtcactgtcttgtacccttgtg
cctcgctcaggggagcaggctgaagggtccccaggtggacctggagactctcagggtcga
aaacggcggcagaccagcatgacagatttctaccactccaaacgccggctgatcttctcc
aagaggaagccctaa

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