Entry |
|
Name |
Mutation-activated AR to androgen receptor signaling pathway
|
Definition |
(T,DHT,E2,P4,FLUT,DHA,A4,F,E) -> AR* => KLK3 |
Expanded |
(C00535,C03917,C00951,C00410,C07653,C01227,C00280,C00735,C00762) -> 367v2 => 354 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
367 | AR; androgen receptor |
354 | KLK3; kallikrein related peptidase 3 |
|
Variant |
|
Metabolite |
|
Reference |
|
Authors |
Nelson WG, De Marzo AM, Isaacs WB. |
Title |
Prostate cancer. |
Journal |
|
Reference |
|
Authors |
Culig Z, Hobisch A, Cronauer MV, Cato AC, Hittmair A, Radmayr C, Eberle J, Bartsch G, Klocker H |
Title |
Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. |
Journal |
|
Reference |
|
Authors |
Pienta KJ, Bradley D. |
Title |
Mechanisms underlying the development of androgen-independent prostate cancer. |
Journal |
|
Reference |
|
Authors |
Feldman BJ, Feldman D. |
Title |
The development of androgen-independent prostate cancer. |
Journal |
|
Reference |
|
Authors |
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP. |
Title |
Androgen receptor gene and hormonal therapy failure of prostate cancer. |
Journal |
Am J Pathol 152:1-9 (1998) |
LinkDB |
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