 | | NETWORK: N00125 | |
| Entry |
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| Name |
IGH-MMSET fusion to transcriptional activation
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| Definition |
IGH-MMSET -> H3 => CCND2 |
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| Expanded |
7468v1 -> (126961,3020,3021,333932,440093,653604,8290,8350,8351,8352,8353,8354,8355,8356,8357,8358,8968) => 894 |
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| Class |
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| Type |
Variant
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| Disease |
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| Gene |
| 7468 | NSD2; nuclear receptor binding SET domain protein 2 |
| 126961 | HIST2H3C; histone cluster 2 H3 family member c |
| 3020 | H3F3A; H3 histone family member 3A |
| 3021 | H3F3B; H3 histone family member 3B |
| 333932 | HIST2H3A; histone cluster 2 H3 family member a |
| 440093 | H3F3C; H3 histone family member 3C |
| 653604 | HIST2H3D; histone cluster 2 H3 family member d |
| 8290 | HIST3H3; histone cluster 3 H3 |
| 8350 | HIST1H3A; histone cluster 1 H3 family member a |
| 8351 | HIST1H3D; histone cluster 1 H3 family member d |
| 8352 | HIST1H3C; histone cluster 1 H3 family member c |
| 8353 | HIST1H3E; histone cluster 1 H3 family member e |
| 8354 | HIST1H3I; histone cluster 1 H3 family member i |
| 8355 | HIST1H3G; histone cluster 1 H3 family member g |
| 8356 | HIST1H3J; histone cluster 1 H3 family member j |
| 8357 | HIST1H3H; histone cluster 1 H3 family member h |
| 8358 | HIST1H3B; histone cluster 1 H3 family member b |
| 8968 | HIST1H3F; histone cluster 1 H3 family member f |
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| Variant |
7468v1 (IGH-MMSET) IGH-MMSET fusion
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| Reference |
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| Authors |
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD |
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| Title |
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. |
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| Journal |
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| Reference |
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| Authors |
Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ |
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| Title |
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells. |
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| Journal |
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| LinkDB |
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