| Entry |
|
| Name |
Amplified MYCN to transcriptional activation
|
| Definition |
MYCN* == MAX => (MDM2,PTK2,TP53,BMI1) |
| Expanded |
4613v1 == 4149 => (4193,5747,7157,648) |
| Class |
|
| Type |
Variant
|
| Disease |
|
| Gene |
| 4613 | MYCN; MYCN proto-oncogene, bHLH transcription factor |
| 4149 | MAX; MYC associated factor X |
| 4193 | MDM2; MDM2 proto-oncogene |
| 5747 | PTK2; protein tyrosine kinase 2 |
| 7157 | TP53; tumor protein p53 |
| 648 | BMI1; BMI1 proto-oncogene, polycomb ring finger |
|
| Variant |
4613v1 (MYCN*) MYCN amplification
|
| Reference |
|
| Authors |
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA |
| Title |
The MYCN oncogene and differentiation in neuroblastoma. |
| Journal |
|
| Reference |
|
| Authors |
Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA |
| Title |
MYCN oncoprotein targets and their therapeutic potential. |
| Journal |
|
| Reference |
|
| Authors |
Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM |
| Title |
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. |
| Journal |
|
| Reference |
|
| Authors |
Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM |
| Title |
N-MYC regulates focal adhesion kinase expression in human neuroblastoma. |
| Journal |
|
| Reference |
|
| Authors |
Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA |
| Title |
p53 is a direct transcriptional target of MYCN in neuroblastoma. |
| Journal |
|
| Reference |
|
| Authors |
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T |
| Title |
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. |
| Journal |
|
| LinkDB |
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