KEGG   NETWORK: N00156
Entry
N00156                      Network                                
Name
Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
Definition
LC3 -- ATG4 >> ATG7 >> ATG3 >> (ATG12+ATG5+ATG16L1) -> LC3-II
  Expanded
(84557,81631,643246,440738) -- (115201,23192,84938,84971) >> 10533 >> 64422 >> (9140+9474+55054) -> ((84557,81631,643246,440738)+C00350)
Class
nt06532 Autophagy
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182 Shigella
Type
Reference
Pathway
hsa04140  Autophagy - animal
Gene
84557  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha
81631  MAP1LC3B; microtubule associated protein 1 light chain 3 beta
643246  MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2
440738  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma
115201  ATG4A; autophagy related 4A cysteine peptidase
23192  ATG4B; autophagy related 4B cysteine peptidase
84938  ATG4C; autophagy related 4C cysteine peptidase
84971  ATG4D; autophagy related 4D cysteine peptidase
10533  ATG7; autophagy related 7
64422  ATG3; autophagy related 3
9140  ATG12; autophagy related 12
9474  ATG5; autophagy related 5
55054  ATG16L1; autophagy related 16 like 1
Metabolite
C00350  Phosphatidylethanolamine
Reference
PMID:24663220
  Authors
Kim KH, Lee MS
  Title
Autophagy--a key player in cellular and body metabolism.
  Journal
Nat Rev Endocrinol 10:322-37 (2014)
DOI:10.1038/nrendo.2014.35
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:25747593
  Authors
Noda NN, Inagaki F
  Title
Mechanisms of Autophagy.
  Journal
Annu Rev Biophys 44:101-22 (2015)
DOI:10.1146/annurev-biophys-060414-034248
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