KEGG   NETWORK: N00172
Entry
N00172                      Network                                

Name
KSHV K15 to PLCG-calcineurin signaling pathway
Definition
K15 -> PLCG1 -> IP3 -> Ca2+ -> CALM -- CN -> NFAT
  Expanded
K21651 -> 5335 -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06220 Calcium signaling
nt06120 Calcium signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
5335  PLCG1; phospholipase C gamma 1
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T-cells 1
4773  NFATC2; nuclear factor of activated T-cells 2
4775  NFATC3; nuclear factor of activated T-cells 3
4776  NFATC4; nuclear factor of activated T-cells 4
Perturbant
K21651 (K15)  K15; KSHV signal transducing membrane protein
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
  Authors
Hogan PG, Chen L, Nardone J, Rao A
  Title
Transcriptional regulation by calcium, calcineurin, and NFAT.
  Journal
Genes Dev 17:2205-32 (2003)
DOI:10.1101/gad.1102703
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