Entry Name KSHV K15 to PLCG-calcineurin signaling pathway
Definition K15 -> PLCG1 -> IP3 -> Ca2+ -> CALM -- CN -> NFAT
Expanded K21651 -> 5335 -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class nt06220 Calcium signaling
nt06120 Calcium signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type Pathogen
Pathway hsa05167 Kaposi sarcoma-associated herpesvirus infection
Disease Gene 5335 PLCG1; phospholipase C gamma 1
5530 PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532 PPP3CB; protein phosphatase 3 catalytic subunit beta
5533 PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535 PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772 NFATC1; nuclear factor of activated T-cells 1
4773 NFATC2; nuclear factor of activated T-cells 2
4775 NFATC3; nuclear factor of activated T-cells 3
4776 NFATC4; nuclear factor of activated T-cells 4
Perturbant K21651 (K15) K15; KSHV signal transducing membrane protein
Metabolite C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
Title Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
Journal Reference Authors Abere B, Schulz TF
Title KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
Journal Reference Authors Hogan PG, Chen L, Nardone J, Rao A
Title Transcriptional regulation by calcium, calcineurin, and NFAT.
Journal LinkDB All DBs
