| Entry |
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| Name |
KSHV vIL-6 to Jak-STAT signaling pathway
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| Definition |
vIL6 -> IL6ST -> JAK2 -> STAT3 |
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| Expanded |
K21670 -> 3572 -> 3717 -> 6774 |
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| Class |
nt06518 JAK-STAT signaling
nt06219 JAK-STAT signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
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| Type |
Pathogen
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| Pathway |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
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| Disease |
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| Gene |
| 3572 | IL6ST; interleukin 6 signal transducer |
| 3717 | JAK2; Janus kinase 2 |
| 6774 | STAT3; signal transducer and activator of transcription 3 |
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| Perturbant |
| K21670 (vIL6) | vIL6; KSHV interleukin 6 |
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| Reference |
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| Authors |
Wu J, Xu Y, Mo D, Huang P, Sun R, Huang L, Pan S, Xu J |
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| Title |
Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation. |
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| Journal |
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| Reference |
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| Authors |
Sodhi A, Montaner S, Gutkind JS |
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| Title |
Viral hijacking of G-protein-coupled-receptor signalling networks. |
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| Journal |
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| Reference |
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| Authors |
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M |
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| Title |
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation. |
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| Journal |
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| LinkDB |
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