| Entry |
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| Name |
PTEN-PIP3-AKT signaling pathway
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| Definition |
PTEN -| PIP3 -> AKT |
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| Expanded |
5728 -| C05981 -> (207,208,10000) |
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| Class |
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| Type |
Reference
|
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| Pathway |
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| Gene |
| 5728 | PTEN; phosphatase and tensin homolog |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Georgescu MM |
|---|
| Title |
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. |
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| Journal |
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|---|
| Reference |
|
|---|
| Authors |
Song MS, Salmena L, Pandolfi PP |
|---|
| Title |
The functions and regulation of the PTEN tumour suppressor. |
|---|
| Journal |
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| Reference |
|
|---|
| Authors |
Hollander MC, Blumenthal GM, Dennis PA |
|---|
| Title |
PTEN loss in the continuum of common cancers, rare syndromes and mouse models. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Lasarge CL, Danzer SC |
|---|
| Title |
Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. |
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| Journal |
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| LinkDB |
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