Entry |
|
Name |
PTEN-PIP3-AKT signaling pathway
|
Definition |
PTEN -| PIP3 -> AKT |
Expanded |
5728 -| C05981 -> (207,208,10000) |
Class |
|
Type |
Reference
|
Pathway |
|
Gene |
5728 | PTEN; phosphatase and tensin homolog |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Georgescu MM |
Title |
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. |
Journal |
|
Reference |
|
Authors |
Song MS, Salmena L, Pandolfi PP |
Title |
The functions and regulation of the PTEN tumour suppressor. |
Journal |
|
Reference |
|
Authors |
Hollander MC, Blumenthal GM, Dennis PA |
Title |
PTEN loss in the continuum of common cancers, rare syndromes and mouse models. |
Journal |
|
Reference |
|
Authors |
Lasarge CL, Danzer SC |
Title |
Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. |
Journal |
|
LinkDB |
|