| Entry |
|
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| Name |
TGFA-EGFR-PLCG-PKC signaling pathway
|
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| Definition |
TGFA -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> ELK1 |
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| Expanded |
7039 -> 1956 -> (5335,5336) -> C01245 -> (C00076,C00165) -> (5578,5579,5582) -> 2002 |
|---|
| Class |
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| Type |
Reference
|
|---|
| Pathway |
|
|---|
| Gene |
| 7039 | TGFA; transforming growth factor alpha |
| 1956 | EGFR; epidermal growth factor receptor |
| 5335 | PLCG1; phospholipase C gamma 1 |
| 5336 | PLCG2; phospholipase C gamma 2 |
| 5578 | PRKCA; protein kinase C alpha |
| 5579 | PRKCB; protein kinase C beta |
| 5582 | PRKCG; protein kinase C gamma |
| 2002 | ELK1; ELK1, ETS transcription factor |
|
|---|
| Metabolite |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Mascia F, Denning M, Kopan R, Yuspa SH |
|---|
| Title |
The black box illuminated: signals and signaling. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Lemmon MA, Schlessinger J |
|---|
| Title |
Cell signaling by receptor tyrosine kinases. |
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| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Chong CR, Janne PA |
|---|
| Title |
The quest to overcome resistance to EGFR-targeted therapies in cancer. |
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| Journal |
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| LinkDB |
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