Entry |
|
Symbol |
PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
|
Name |
(RefSeq) phospholipase C gamma 2
|
KO |
|
Organism |
|
Pathway |
hsa01521 | EGFR tyrosine kinase inhibitor resistance |
hsa04070 | Phosphatidylinositol signaling system |
hsa04072 | Phospholipase D signaling pathway |
hsa04613 | Neutrophil extracellular trap formation |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa04662 | B cell receptor signaling pathway |
hsa04664 | Fc epsilon RI signaling pathway |
hsa04666 | Fc gamma R-mediated phagocytosis |
hsa04670 | Leukocyte transendothelial migration |
hsa04750 | Inflammatory mediator regulation of TRP channels |
hsa04919 | Thyroid hormone signaling pathway |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
hsa04935 | Growth hormone synthesis, secretion and action |
hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05170 | Human immunodeficiency virus 1 infection |
|
Module |
hsa_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Network |
|
Element |
N00023 | EGF-EGFR-PLCG-ERK signaling pathway |
N00024 | Mutation-activated EGFR to PLCG-ERK signaling pathway |
N00025 | EML4-ALK fusion kinase to PLCG-ERK signaling pathway |
N00026 | EGF-EGFR-PLCG-CAMK signaling pathway |
N00027 | Amplified EGFR to PLCG-CAMK signaling pathway |
N00028 | PDGF-PDGFR-PLCG-CAMK signaling pathway |
N00029 | Amplified PDGFR to PLCG-CAMK signaling pathway |
N00147 | EGF-EGFR-PLCG-calcineurin signaling pathway |
N00180 | KSHV K1 to PLCG-calcineurin signaling pathway |
N00227 | TGFA-EGFR-PLCG-PKC signaling pathway |
N00228 | TGFA-overexpression to PLCG-PKC signaling pathway |
N00401 | CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway |
N00487 | BCR-PLCG-Calcineurin signaling pathway |
N00546 | CXCL12-CXCR4-PKC-ERK signaling pathaway |
N01106 | TCR-PLCG-ITPR signaling pathway |
N01641 | RTK-PLCG-ITPR signaling pathway |
N01765 | CXCR4-GNAQ-PLCB/G signaling pathway |
|
Disease |
H01743 | Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation |
H02159 | Familial cold autoinflammatory syndrome |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
5336 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
5336 (PLCG2)
04064 NF-kappa B signaling pathway
5336 (PLCG2)
04066 HIF-1 signaling pathway
5336 (PLCG2)
04070 Phosphatidylinositol signaling system
5336 (PLCG2)
04072 Phospholipase D signaling pathway
5336 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5336 (PLCG2)
04613 Neutrophil extracellular trap formation
5336 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
5336 (PLCG2)
04662 B cell receptor signaling pathway
5336 (PLCG2)
04664 Fc epsilon RI signaling pathway
5336 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
5336 (PLCG2)
04670 Leukocyte transendothelial migration
5336 (PLCG2)
04062 Chemokine signaling pathway
5336 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
5336 (PLCG2)
04919 Thyroid hormone signaling pathway
5336 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
5336 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5336 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
5336 (PLCG2)
04380 Osteoclast differentiation
5336 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5336 (PLCG2)
05206 MicroRNAs in cancer
5336 (PLCG2)
05205 Proteoglycans in cancer
5336 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
5336 (PLCG2)
05214 Glioma
5336 (PLCG2)
05223 Non-small cell lung cancer
5336 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
5336 (PLCG2)
05171 Coronavirus disease - COVID-19
5336 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
5336 (PLCG2)
05169 Epstein-Barr virus infection
5336 (PLCG2)
09171 Infectious disease: bacterial
05110 Vibrio cholerae infection
5336 (PLCG2)
05120 Epithelial cell signaling in Helicobacter pylori infection
5336 (PLCG2)
05131 Shigellosis
5336 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
5336 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
5336 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
5336 (PLCG2)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
5336 (PLCG2)
Membrane trafficking [BR:hsa04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
5336 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
5336 (PLCG2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
16:81739041..81962685
|
AA seq |
1265 aa
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
SKFYS |
NT seq |
3798 nt +upstreamnt +downstreamnt
atgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccccgagcgg
agaaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctatat
ggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaggatgcagtt
aactggctctctggcttgaaaatcttacaccaggaagcgatgaatgcgtccacgcccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcg
tccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatc
aagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggcc
ttcaaggaagtatttggcgacctgctgttgacgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgatgtggatgtcaacatggaggacaagaaggacgaacacaagcaacagggggag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccattgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggat
ataccccctacagaactacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctg
atgaggattccccgggacggggccttcctgatccggaagcgagaggggagcgactcctat
gccatcaccttcagggctaggggcaaggtaaagcattgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagcag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacggcagataagtac
atgcagatgaatcacgcattgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaagtggagatctgtggagccgagtatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagat
atgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcagtcaaatca
ggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag |