KEGG   NETWORK: N00240
Entry
N00240                      Network                                
Name
TERT-overexpression to telomerase activity
Definition
(TERT*+TERC) -> DNA
  Expanded
(7015v1+7012) -> C00039
Class
nt06261 Gastric cancer
nt06263 Hepatocellular carcinoma
nt06232 Telomerase activity (cancer)
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Disease
H00048  Hepatocellular carcinoma
H00018  Gastric cancer
Gene
7015  TERT; telomerase reverse transcriptase
7012  TERC; telomerase RNA component
Variant
7015v1 (TERT*)  TERT overexpression
Metabolite
C00039  DNA
Reference
  Authors
Shay JW, Wright WE
  Title
Role of telomeres and telomerase in cancer.
  Journal
Semin Cancer Biol 21:349-53 (2011)
DOI:10.1016/j.semcancer.2011.10.001
Reference
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
  Authors
Mu J, Wei LX
  Title
Telomere and telomerase in oncology.
  Journal
Cell Res 12:1-7 (2002)
DOI:10.1038/sj.cr.7290104
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