| Entry |
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| Name |
KEAP1-NRF2 signaling pathway
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| Definition |
(O2-,HO2,H2O2,OH,ACRL,4HNE,NO) -| KEAP1 -| NRF2 => (HMOX1,NQO1,GST,TXNRD1) |
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| Expanded |
(C00704,C21641,C00027,C16844,C01471,C21642,C00533) -| 9817 -| 4780 => (3162,1728,119391,221357,2938,2939,2940,2941,2944,2946,2947,2948,2949,2950,2952,2953,4257,4258,4259,653689,9446,7296) |
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| Class |
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| Type |
Reference
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| Gene |
| 9817 | KEAP1; kelch like ECH associated protein 1 |
| 4780 | NFE2L2; nuclear factor, erythroid 2 like 2 |
| 3162 | HMOX1; heme oxygenase 1 |
| 1728 | NQO1; NAD(P)H quinone dehydrogenase 1 |
| 119391 | GSTO2; glutathione S-transferase omega 2 |
| 221357 | GSTA5; glutathione S-transferase alpha 5 |
| 2938 | GSTA1; glutathione S-transferase alpha 1 |
| 2939 | GSTA2; glutathione S-transferase alpha 2 |
| 2940 | GSTA3; glutathione S-transferase alpha 3 |
| 2941 | GSTA4; glutathione S-transferase alpha 4 |
| 2944 | GSTM1; glutathione S-transferase mu 1 |
| 2946 | GSTM2; glutathione S-transferase mu 2 |
| 2947 | GSTM3; glutathione S-transferase mu 3 |
| 2948 | GSTM4; glutathione S-transferase mu 4 |
| 2949 | GSTM5; glutathione S-transferase mu 5 |
| 2950 | GSTP1; glutathione S-transferase pi 1 |
| 2952 | GSTT1; glutathione S-transferase theta 1 |
| 2953 | GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) |
| 4257 | MGST1; microsomal glutathione S-transferase 1 |
| 4258 | MGST2; microsomal glutathione S-transferase 2 |
| 4259 | MGST3; microsomal glutathione S-transferase 3 |
| 653689 | GSTT2B; glutathione S-transferase theta 2B (gene/pseudogene) |
| 9446 | GSTO1; glutathione S-transferase omega 1 |
| 7296 | TXNRD1; thioredoxin reductase 1 |
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| Metabolite |
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| Reference |
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| Authors |
Taguchi K, Motohashi H, Yamamoto M |
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| Title |
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. |
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| Journal |
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| Reference |
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| Authors |
McMahon M, Lamont DJ, Beattie KA, Hayes JD |
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| Title |
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. |
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| Journal |
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| Reference |
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| Authors |
Ganan-Gomez I, Wei Y, Yang H, Boyano-Adanez MC, Garcia-Manero G |
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| Title |
Oncogenic functions of the transcription factor Nrf2. |
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| Journal |
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| Reference |
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| Authors |
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL |
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| Title |
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer. |
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| Journal |
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| Reference |
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| Authors |
Kim HJ, Vaziri ND |
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| Title |
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. |
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| Journal |
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| Reference |
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| Authors |
Praslicka BJ, Kerins MJ, Ooi A |
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| Title |
The complex role of NRF2 in cancer: a genomic view |
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| Journal |
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| LinkDB |
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