NETWORK: N00244
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Entry
N00244 Network
Name
Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
Definition
KEAP1* // NRF2 => (HMOX1,
NQO1,
GST,
TXNRD1)
Expanded
9817v1 // 4780 => (3162,
1728,
119391,
221357,
2938,
2939,
2940,
2941,
2944,
2946,
2947,
2948,
2949,
2950,
2952,
2953,
4257,
4258,
4259,
653689,
9446,
7296)
Class
nt06263
Hepatocellular carcinoma
nt06226
KEAP1-NRF2 signaling (cancer)
Type
Variant
Pathway
hsa05225
Hepatocellular carcinoma
Disease
H00048
Hepatocellular carcinoma
Gene
9817
KEAP1; kelch like ECH associated protein 1
4780
NFE2L2; nuclear factor, erythroid 2 like 2
3162
HMOX1; heme oxygenase 1
1728
NQO1; NAD(P)H quinone dehydrogenase 1
119391
GSTO2; glutathione S-transferase omega 2
221357
GSTA5; glutathione S-transferase alpha 5
2938
GSTA1; glutathione S-transferase alpha 1
2939
GSTA2; glutathione S-transferase alpha 2
2940
GSTA3; glutathione S-transferase alpha 3
2941
GSTA4; glutathione S-transferase alpha 4
2944
GSTM1; glutathione S-transferase mu 1
2946
GSTM2; glutathione S-transferase mu 2
2947
GSTM3; glutathione S-transferase mu 3
2948
GSTM4; glutathione S-transferase mu 4
2949
GSTM5; glutathione S-transferase mu 5
2950
GSTP1; glutathione S-transferase pi 1
2952
GSTT1; glutathione S-transferase theta 1
2953
GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
4257
MGST1; microsomal glutathione S-transferase 1
4258
MGST2; microsomal glutathione S-transferase 2
4259
MGST3; microsomal glutathione S-transferase 3
653689
GSTT2B; glutathione S-transferase theta 2B (gene/pseudogene)
9446
GSTO1; glutathione S-transferase omega 1
7296
TXNRD1; thioredoxin reductase 1
Variant
9817v1
(KEAP1*) KEAP1 mutation
Reference
PMID:
24024136
Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
Journal
Redox Biol 1:45-9 (2013)
DOI:
10.1016/j.redox.2012.10.001
Reference
Authors
Praslicka BJ, Kerins MJ, Ooi A
Title
The complex role of NRF2 in cancer: a genomic view
Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:
10.1016/j.cotox.2016.09.003
Reference
PMID:
25846427
Authors
Nault JC, Rebouissou S, Zucman Rossi J
Title
NRF2/KEAP1 and Wnt/beta-catenin in the multistep process of liver carcinogenesis in humans and rats.
Journal
Hepatology 62:677-9 (2015)
DOI:
10.1002/hep.27828
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