KEGG   NETWORK: N00269
Entry
N00269                      Network                                
Name
HCV core to TNF-NFKB signaling pathway
Definition
Core -> NFKB
  Expanded
K22271 -> (4790+5970)
Class
nt06263 Hepatocellular carcinoma
nt06123 TNF signaling (viruses and bacteria)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K22271 (Core)  Core; HCV core protein
Reference
  Authors
Marusawa H, Hijikata M, Chiba T, Shimotohno K
  Title
Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation.
  Journal
J Virol 73:4713-20 (1999)
DOI:10.1128/JVI.73.6.4713-4720.1999
Reference
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
  Authors
Tran G.
  Title
The role of hepatitis C virus in the pathogenesis of hepatocellular carcinoma
  Journal
Biosci Horiz 1:167-175 (2008)
DOI:10.1093/biohorizons/hzn020
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