KEGG   ORTHOLOGY: K22271
Entry
K22271            Tight     KO                                     

Symbol
Core
Name
HCV core protein
Pathway
map03230  Viral genome structure
map05160  Hepatitis C
map05203  Viral carcinogenesis
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06140  Transcription (viruses)
nt06163  Hepatitis C virus (HCV)
nt06222  IFN signaling
nt06263  Hepatocellular carcinoma
  Element
N00269  HCV core to TNF-NFKB signaling pathway
N00270  HCV Core to IFN signaling pathway
N00518  HCV Core to ERK signaling pathway
N00519  HCV Core to ERK signaling pathway
N00521  HCV Core to p21-cell cycle G1/S
N00523  HCV Core to p21-cell cycle G1/S
N00527  HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
N00528  HCV core to extrinsic apoptotic pathway
N00529  HCV core to RXRA/PPARA-mediated transcription
N00530  HCV core to RXRA/LXRA-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22271  Core; HCV core protein
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22271  Core; HCV core protein
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22271  Core; HCV core protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22271  Core; HCV core protein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22271  Core; HCV core protein
Genes
VP: 951475-1(p21)
Reference
  Authors
Gouklani H, Beyer C, Drummer H, Gowans EJ, Netter HJ, Haqshenas G
  Title
Identification of specific regions in hepatitis C virus core, NS2 and NS5A that genetically interact with p7 and co-ordinate infectious virus production.
  Journal
J Viral Hepat 20:e66-71 (2013)
DOI:10.1111/jvh.12004
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB

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