KEGG   NETWORK: N00361
Entry
N00361                      Network                                

Name
HPV E7 to cell cycle G1/S
Definition
E7 -> (RB1,RBL1,RBL2) // E2F
  Expanded
K21809 -> (5925,5933,5934) // (1869,1870,1871)
Class
nt06130 Cell cycle (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
5925  RB1; RB transcriptional corepressor 1
5933  RBL1; RB transcriptional corepressor like 1
5934  RBL2; RB transcriptional corepressor like 2
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21809 (E7)  E7; HPV protein E7
Reference
  Authors
Boshoff C, Weiss R
  Title
AIDS-related malignancies.
  Journal
Nat Rev Cancer 2:373-82 (2002)
DOI:10.1038/nrc797
Reference
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
  Authors
de Freitas AC, Coimbra EC, Leitao Mda C
  Title
Molecular targets of HPV oncoproteins: potential biomarkers for cervical carcinogenesis.
  Journal
Biochim Biophys Acta 1845:91-103 (2014)
DOI:10.1016/j.bbcan.2013.12.004
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