KEGG   DISEASE: Cervical cancer
Entry
H00030                      Disease                                
Name
Cervical cancer
Description
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of the breast and female genital organs
   H00030  Cervical cancer
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of female genital organs
     2C77  Malignant neoplasms of cervix uteri
      H00030  Cervical cancer
Cancer-associated carbohydrates [br08441.html]
 H00030
Pathway
hsa05165  Human papillomavirus infection
Network
nt06166 Human papillomavirus (HPV)
nt06511 NOTCH signaling
nt06516 TNF signaling
nt06517 TLR signaling
Gene
K-ras (mutation) [HSA:3845] [KO:K07827]
H-ras (mutation) [HSA:3265] [KO:K02833]
EGFR (amplification) [HSA:1956] [KO:K04361]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
p21 (overexpression) [HSA:1026] [KO:K06625]
CDK4 (overexpression) [HSA:1019] [KO:K02089]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
Pathogen
Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]
Drug
Recombinant adsorbed quadrivalent human papillomavirus virus-like particle vaccine [DR:D10192]
Human papillomavirus 9-valent vaccine, recombinant [DR:D11863]
Topotecan hydrochloride [DR:D02168]
Pembrolizumab [DR:D10574] (PD-L1 expressed)
Bevacizumab [DR:D06409]
Tisotumab vedotin [DR:D11814]
Other DBs
ICD-11: 2C77
ICD-10: C53
MeSH: D002583
Reference
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
  Authors
Lazo PA.
  Title
The molecular genetics of cervical carcinoma.
  Journal
Br J Cancer 80:2008-18 (1999)
DOI:10.1038/sj.bjc.6690635
Reference
  Authors
Patel P, Moazzam N, Potti A, Mehdi SA.
  Title
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  Journal
Am J Clin Oncol 28:427-8 (2005)
DOI:10.1097/01.coc.0000168670.28659.8d
Reference
  Authors
Schrager S, Potter BE.
  Title
Diethylstilbestrol exposure.
  Journal
Am Fam Physician 69:2395-400 (2004)
Reference
  Authors
Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN.
  Title
Cancer risk in women prenatally exposed to diethylstilbestrol.
  Journal
Int J Cancer 121:356-60 (2007)
DOI:10.1002/ijc.22631
Reference
  Authors
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
  Title
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
  Journal
J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110
Reference
  Authors
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
  Title
Environmental and chemical carcinogenesis.
  Journal
Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010
Reference
  Authors
Sasco AJ, Secretan MB, Straif K.
  Title
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
  Journal
Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998
Reference
  Authors
Baldwin P, Laskey R, Coleman N.
  Title
Translational approaches to improving cervical screening.
  Journal
Nat Rev Cancer 3:217-26 (2003)
DOI:10.1038/nrc1010
Reference
  Authors
Garland SM.
  Title
Can we really beat cervical cancer?
  Journal
Med J Aust 178:647-9 (2003)
DOI:10.5694/j.1326-5377.2003.tb05396.x
Reference
  Authors
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.
  Title
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
  Journal
Biomed Pharmacother 58:24-38 (2004)
DOI:10.1016/j.biopha.2003.11.003
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