KEGG   DISEASE: Cervical cancer
H00030                      Disease                                

Cervical cancer
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.
Human diseases [BR:br08402]
  Cancers of the breast and female genital organs
   H00030  Cervical cancer
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of female genital organs
     2C77  Malignant neoplasms of cervix uteri
      H00030  Cervical cancer
Cancer-associated carbohydrates [br08441.html]
hsa05200  Pathways in cancer
hsa05165  Human papillomavirus infection
hsa05203  Viral carcinogenesis
nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06116  NOTCH signaling (viruses)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06140  Transcription (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06166  Human papillomavirus (HPV)
N00341  HPV E6 to the Scribble/Dlg/Lgl polarity module
N00343  HPV E6 to MAGI-PTEN signaling pathway
N00345  HPV E6 to CRB3-Pals1-PATJ complex
N00346  HPV E6 to TLR-IRF3 signaling pathway
N00348  HPV E6 to p300-p21-Cell cycle G1/S
N00349  HPV E6 to p300-p21-Cell cycle G1/S
N00350  HPV E6 to extrinsic apoptotic pathway
N00351  HPV E6 to extrinsic apoptotic pathway
N00352  HPV E6 to extrinsic apoptotic pathway
N00353  HPV E6 to PTEN-PIP3-AKT signaling pathway
N00354  HPV E6 to PTEN-PIP3-AKT signaling pathway
N00356  HPV E7 to PP2A-AKT signaling patyway
N00357  HPV E6 to MTOR signaling pathway
N00358  HPV E6 to p21-cell cycle G1/S
N00359  HPV E7 to p27-cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00361  HPV E7 to cell cycle G1/S
N00362  HPV E5 to p21-cell cycle G1/S
N00364  HPV E5 to antigen processing and presentation by MHC class I molecules
N00365  HPV E7 to cell cycle G1/S
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00368  HPV E5 to PDGFR-PI3K signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00371  HPV E7 to pyruvate generation
N00372  HPV E7 to p300-p21-Cell cycle G1/S
N00373  HPV E6 to NFX1-mediated transcription
N00375  HPV E7 to TNF-IRF1 signaling pathway
N00376  HPV E7 to TBP1-mediated transcription
N00377  HPV E6 to IFN signaling pathway
N00378  HPV E6 to IFN signaling pathway
N00379  HPV E7 to IFN signaling pathway
N00380  HPV E6 to Notch signaling pathway
N00381  HPV E6 to Notch signaling pathway
N00382  HPV E6 to Notch signaling pathway
N00383  HPV E6 to intrinsic apoptotic pathway
N00384  HPV E6 to intrinsic apoptotic pathway
K-ras (mutation) [HSA:3845] [KO:K07827]
H-ras (mutation) [HSA:3265] [KO:K02833]
EGFR (amplification) [HSA:1956] [KO:K04361]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
p21 (overexpression) [HSA:1026] [KO:K06625]
CDK4 (overexpression) [HSA:1019] [KO:K02089]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
Azathioprine [CPD:C06837]
Diethylstilboestrol [CPD:C07620]
Estrogens, nonsteroidal
Tobacco smoking and tobacco smoke
Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]
Recombinant adsorbed quadrivalent human papillomavirus virus-like particle vaccine [DR:D10192]
Topotecan hydrochloride [DR:D02168]
Pembrolizumab [DR:D10574] (PD-L1 expressed)
Bevacizumab [DR:D06409]
Tisotumab vedotin [DR:D11814]
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma, not otherwise specified
ICD-O: 8140/3, Tumor type: Adenocarcinoma
Other DBs
ICD-11: 2C77
ICD-10: C53
MeSH: D002583
PMID:11486705 (gene, carcinogen)
Wolf JK, Ramirez PT.
The molecular biology of cervical cancer.
Cancer Invest 19:621-9 (2001)
PMID:10471054 (gene, carcinogen)
Lazo PA.
The molecular genetics of cervical carcinoma.
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PMID:16062089 (carcinogen)
Patel P, Moazzam N, Potti A, Mehdi SA.
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
Am J Clin Oncol 28:427-8 (2005)
PMID:15168959 (carcinogen)
Schrager S, Potter BE.
Diethylstilbestrol exposure.
Am Fam Physician 69:2395-400 (2004)
PMID:17390375 (carcinogen)
Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN.
Cancer risk in women prenatally exposed to diethylstilbestrol.
Int J Cancer 121:356-60 (2007)
PMID:11281434 (carcinogen)
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
J Cutan Med Surg 5:43-60 (2001)
PMID:15489140 (carcinogen)
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
Environmental and chemical carcinogenesis.
Semin Cancer Biol 14:473-86 (2004)
PMID:15552776 (carcinogen)
Sasco AJ, Secretan MB, Straif K.
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
Lung Cancer 45 Suppl 2:S3-9 (2004)
PMID:12612656 (marker)
Baldwin P, Laskey R, Coleman N.
Translational approaches to improving cervical screening.
Nat Rev Cancer 3:217-26 (2003)
PMID:12797857 (marker)
Garland SM.
Can we really beat cervical cancer?
Med J Aust 178:647-9 (2003)
PMID:14739059 (marker)
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
Biomed Pharmacother 58:24-38 (2004)

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